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MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival Medical Sciences
Oncogenic mutations in the small GTPase KRAS are frequently found in human cancers, and, currently, there are no effective targeted therapies for these tumors. Using a combinatorial siRNA approach, we analyzed a panel of KRAS mutant colorectal and pancreatic cancer cell lines for their dependency on 28 gene nodes that...
Source: Proceedings of the National Academy of Sciences - March 4, 2019 Category: Science Authors: Chih-Shia Lee, Liam C. Lee, Tina L. Yuan, Sirisha Chakka, Christof Fellmann, Scott W. Lowe, Natasha J. Caplen, Frank McCormick, Ji Luo Tags: PNAS Plus Source Type: research

Effect of siRNA-mediated knockdown of eIF3c gene on survival of colon cancer cells.
This study was focused on investigating the effect of small interfering RNA (siRNA)-mediated eIF3c gene knockdown on colon cancer cell survival. The eIF3c gene was observed to be highly expressed in colon cancer cell models. The expression levels of the gene in eIF3c siRNA infected and control siRNA infected cells were compared via real-time polymerase chain reaction (PCR) and western blotting analysis. Cell proliferation levels were analyzed employing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and colony formation assays. Furthermore, the effects of eIF3c gene knockdown on the cell cycle and apopto...
Source: J Zhejiang Univ Sci ... - June 1, 2013 Category: Science Authors: Song N, Wang Y, Gu XD, Chen ZY, Shi LB Tags: J Zhejiang Univ Sci B Source Type: research