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Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis
This study was mainly conducted in primary human endometrial stromal cells. Therefore, the function of FPNin vivo need to be further investigated.WIDER IMPLICATIONS OF THE FINDINGSOur findings reveal that erastin may serve as a potential therapeutic treatment for endometriosis.STUDY FUNDING/COMPETING INTEREST(S)This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors. The authors declare no conflict of interest.
Source: Human Reproduction - December 30, 2020 Category: Reproduction Medicine Source Type: research

Iron suppresses ovarian granulosa cell proliferation and arrests cell cycle through regulating p38 MAPK/p53/p21 pathway.
Abstract Iron is an essential nutrient that may exert toxic effects when it accumulates in tissues. Little is known regarding its effects on gonadal function. Both Fe2+ and Fe3+ could be released from iron deposition. We employed mouse non-luteinized granulosa cell for in vitro studies and human ovarian tissues for Prussian blue and immunohistochemical staining to identify the iron deposition and effect in vivo. After treatment with FeSO4-7H2O or FeCl3 in granulosa cell cultured with follicle stimulating hormone (FSH) for 48 hours, we found that Fe2+ significantly suppressed FSH-induced granulosa cell proliferatio...
Source: Biology of Reproduction - August 28, 2017 Category: Reproduction Medicine Authors: Chen MJ, Chou CH, Shun CT, Mao TL, Wen WF, Chen CD, Chen SU, Yang YS, Ho HN Tags: Biol Reprod Source Type: research