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Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis
This study was mainly conducted in primary human endometrial stromal cells. Therefore, the function of FPNin vivo need to be further investigated.WIDER IMPLICATIONS OF THE FINDINGSOur findings reveal that erastin may serve as a potential therapeutic treatment for endometriosis.STUDY FUNDING/COMPETING INTEREST(S)This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors. The authors declare no conflict of interest.
Source: Human Reproduction - December 30, 2020 Category: Reproduction Medicine Source Type: research

Osteoprotegerin interacts with syndecan-1 to promote human endometrial stromal decidualization by decreasing Akt phosphorylation
In this study, based on a number of approaches, it was demonstrated that OPG mediated the repression of Akt that occurs during human stromal cell decidualization, however, the molecular link between OPG and Akt signaling was not determined, and still requires further exploration.WIDER IMPLICATIONS OF THE FINDINGSOPG is required for decidualization, and a decrease in OPG levels is associated with RPL. These findings provide a new candidate molecule for the diagnosis and potential treatment of RPL.STUDY FUNDING/COMPETING INTEREST(S)This work was supported in part by the National Natural Science Foundation of China U1605223 (...
Source: Human Reproduction - October 13, 2020 Category: Reproduction Medicine Source Type: research

Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis
This study was funded by the Academy of Finland and by Tekes: Finnish Funding Agency for Innovation. The authors have no conflict of interest to declare.
Source: Human Reproduction - February 15, 2018 Category: Reproduction Medicine Source Type: research

Changes in keratin 8/18 expression in human granulosa cell lineage are associated to cell death/survival events: potential implications for the maintenance of the ovarian reserve
This study describes, for the first time, the existence of sub-populations of primordial follicles on the basis of K8/K18 expression in granulosa cells, and that their proportions change with age. While a progressive increase in K8/K18 expression cannot be ruled out, our data are consistent with the hypothesis that primordial follicles expressing low levels of K8/K18 are preferentially ablated by follicle attrition, while primordial follicles showing high K8/K18 levels are those predominantly recruited into the growing pool. This suggests that K8/K18 expression could constitute a novel factor regulating primordial follicle...
Source: Human Reproduction - February 1, 2018 Category: Reproduction Medicine Source Type: research

Trophoblast cells inhibit neutrophil extracellular trap formation and enhance apoptosis through vasoactive intestinal peptide-mediated pathways
STUDY QUESTION Do human trophoblast cells modulate neutrophil extracellular trap (NET) formation, reactive oxygen species (ROS) synthesis and neutrophil apoptosis through mechanisms involving vasoactive intestinal peptide (VIP)? SUMMARY ANSWER Trophoblast cells inhibited NET formation and ROS synthesis and enhanced neutrophil apoptosis through VIP-mediated pathways in a model of maternal–placental interaction. WHAT IS KNOWN ALREADY Immune homeostasis maintenance at the maternal–placental interface is mostly coordinated by trophoblast cells. Neutrophil activation and NET formation increases in pregnancies comp...
Source: Human Reproduction - December 17, 2016 Category: Reproduction Medicine Authors: Calo, G., Sabbione, F., Vota, D., Paparini, D., Ramhorst, R., Trevani, A., Perez Leiros, C. Tags: Early pregnancy Source Type: research

nm23 regulates decidualization through the PI3K-Akt-mTOR signaling pathways in mice and humans
This study was supported by the National Natural Science Foundation of China (grant nos. 81370731, 31571551 and 31571190), the Science and Technology Project of Chongqing Education Committee (KJ130309), open funding by the Chongqing Institute for Family Planning (1201) and the Excellent Young Scholars of Chongqing Medical University (CQYQ201302). The authors have no conflicts of interest to declare.
Source: Human Reproduction - September 18, 2016 Category: Reproduction Medicine Authors: Zhang, X., Fu, L.-J., Liu, X.-Q., Hu, Z.-Y., Jiang, Y., Gao, R.-F., Feng, Q., Lan, X., Geng, Y.-Q., Chen, X.-M., He, J.-L., Wang, Y.-X., Ding, Y.-B. Tags: Reproductive biology Source Type: research

Interleukin-1 receptor antagonist mediates toll-like receptor 3-induced inhibition of trophoblast adhesion to endometrial cells in vitro
This study has been only done in vitro. Future in vivo studies will confirm our data. WIDER IMPLICATIONS OF THE FINDINGS The findings of this study have a potential clinical application in introducing IL-1RA as one of the diagnostic infertility markers in the endometrium, which can affect the process of embryo adhesion at the time of implantation. Moreover, based on the novel data obtained in the current study, blocking and regulating the MAPK pathway by its inhibitors can be used as a new strategy to prevent and treat virus-induced infertility cases in ART techniques. STUDY FUNDING/COMPETING INTEREST This study was part...
Source: Human Reproduction - August 18, 2016 Category: Reproduction Medicine Authors: Montazeri, M., Sanchez-Lopez, J. A., Caballero, I., Maslehat Lay, N., Elliott, S., Fazeli, A. Tags: Reproductive biology Source Type: research

Integrin {alpha}4-positive human trophoblast progenitors: functional characterization and transcriptional regulation
This study supported our hypothesis that TBPCs from the chorionic mesenchyme can contribute to the subpopulation of CTBs that reside in the smooth chorion. In the absence of in vivo data, which is difficult to obtain in humans, the results have the limitations common to all in vitro studies. WIDER IMPLICATIONS OF THE FINDINGS The accepted view is that progenitors reside among the villous CTB subpopulation. Here, we show that TBPCs also reside in the mesenchymal layer of the smooth chorion throughout gestation. We theorize that they can contribute to the CTB layer in this region. This phenomenon may be particularly importa...
Source: Human Reproduction - May 17, 2016 Category: Reproduction Medicine Authors: Genbacev, O., Larocque, N., Ona, K., Prakobphol, A., Garrido-Gomez, T., Kapidzic, M., Barcena, A., Gormley, M., Fisher, S. J. Tags: Reproductive biology Source Type: research

Overexpression of chloride channel-3 is associated with the increased migration and invasion ability of ectopic endometrial cells from patients with endometriosis
STUDY QUESTION Is chloride channel-3 (ClC-3) involved in regulating the biological behavior of endometrial stromal cells (ESCs)? SUMMARY ANSWER ClC-3 promotes endometriotic cell migration and invasion. WHAT IS KNOWN ALREADY ClC-3 plays a significant role in the migration and invasion of various kinds of cells. STUDY DESIGN, SIZE, DURATION An in vitro investigation of the effect of ClC-3 on the migration and invasion of ectopic ESCs from patients with endometriosis. PARTICIPANTS/MATERIALS, SETTING, METHODS The ectopic and eutopic endometrial samples from 43 female patients with endometriosis and the endometrial samples ...
Source: Human Reproduction - April 20, 2016 Category: Reproduction Medicine Authors: Guan, Y.-t., Huang, Y.-q., Wu, J.-b., Deng, Z.-q., Wang, Y., Lai, Z.-y., Wang, H.-b., Sun, X.-x., Zhu, Y.-l., Du, M.-m., Zhu, L.-y., Chen, L.-x., Wang, L.-w. Tags: Gynaecology Source Type: research

Elevated phosphatase of regenerating liver 3 (PRL-3) promotes cytoskeleton reorganization, cell migration and invasion in endometrial stromal cells from endometrioma
STUDY QUESTION Is phosphatase of regenerating liver-3 (PRL-3) associated with increased motility of endometriotic cells from endometrioma? SUMMARY ANSWER Elevated PRL-3 promotes cytoskeleton reorganization, cell migration and invasion of endometrial stromal cells (ESCs) from endometrioma. WHAT IS KNOWN ALREADY Overexpression of PRL-3 is associated with cancer cell migration, invasion and metastatic phenotype. STUDY DESIGN, SIZE, DURATION Primary human ESCs were isolated from eutopic endometrium of women without endometriosis (EuCo, n = 10), with histologically proven endometrioma (EuEM, n = 19) and from the cyst wall of...
Source: Human Reproduction - March 15, 2016 Category: Reproduction Medicine Authors: Zhan, H., Ma, J., Ruan, F., Bedaiwy, M. A., Peng, B., Wu, R., Lin, J. Tags: Gynaecology Source Type: research

Role of Sirt3 in mitochondrial biogenesis and developmental competence of human in vitro matured oocytes
STUDY QUESTION Does Sirt3 dysfunction result in poor developmental outcomes for human oocytes after in vitro maturation (IVM)? SUMMARY ANSWER Inefficient Sirt3 expression induced decreased mitochondrial DNA copy number and biogenesis, and therefore impaired the developmental competence of human IVM oocytes. WHAT IS KNOWN ALREADY Cytoplasmic immaturity in IVM oocytes may lead to reduced developmental competence. Mitochondrial dysfunction results in the accumulation of free radicals and leads to DNA mutations, protein damage, telomere shortening and apoptosis. SIRT3 (in the Sirtuin protein family) has emerged as a mitochon...
Source: Human Reproduction - February 16, 2016 Category: Reproduction Medicine Authors: Zhao, H.-C., Ding, T., Ren, Y., Li, T.-J., Li, R., Fan, Y., Yan, J., Zhao, Y., Li, M., Yu, Y., Qiao, J. Tags: Reproductive biology Source Type: research

Vascular endothelial growth factor (VEGF) regulation by hypoxia inducible factor-1 alpha (HIF1A) starts and peaks during endometrial breakdown, not repair, in a mouse menstrual-like model
This study is not a clinical trial.
Source: Human Reproduction - August 19, 2015 Category: Reproduction Medicine Authors: Chen, X., Liu, J., He, B., Li, Y., Liu, S., Wu, B., Wang, S., Zhang, S., Xu, X., Wang, J. Tags: Reproductive biology Source Type: research

Inhibition of DDAH1, but not DDAH2, results in apoptosis of a human trophoblast cell line in response to TRAIL
This study used the human extravillous trophoblast-derived cell line SGHPL-4 cells. All experiments were performed at least three times. PARTICIPANTS/MATERIALS, SETTING, METHODS The effect of DDAH on trophoblast apoptosis was examined using siRNA and time-lapse microscopy. Changes in the expression of DDAH were followed by PCR and western blot analysis. Receptor expression was followed by flow cytometry. MAIN RESULTS AND THE ROLE OF CHANCE Inhibiting the expression of DDAH1, but not DDAH2, resulted in a significant increase in the sensitivity of the EVT cell line SGHPL-4 to tumour necrosis factor related apoptosis induci...
Source: Human Reproduction - July 19, 2015 Category: Reproduction Medicine Authors: Lumicisi, B. A., Cartwright, J. E., Leslie, K., Wallace, A. E., Whitley, G. S. Tags: Early pregnancy Source Type: research

NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization
STUDY QUESTION Does NEDD8-mediated neddylation regulate human endometrial stromal proliferation and decidualization? SUMMARY ANSWER Neddylation inhibition by a selective NEDD8-activating enzyme inhibitor, MLN4924, significantly impairs human endometrial stromal cell (HESC) proliferation and decidualization and facilitates cell senescence, via p21 accumulation. WHAT IS KNOWN ALREADY Neddylation regulates cell proliferation and tissue remodeling during embryogenesis and tumorigenesis, while human endometrial stroma undergoes sequential proliferation, differentiation, as well as dynamic tissue remodeling during each menstru...
Source: Human Reproduction - June 18, 2015 Category: Reproduction Medicine Authors: Liao, Y., Jiang, Y., He, H., Ni, H., Tu, Z., Zhang, S., Wang, B., Lou, J., Quan, S., Wang, H. Tags: Reproductive biology Source Type: research

Molecular pathways reflecting poor intrauterine growth are found in Wharton's jelly-derived mesenchymal stem cells
STUDY QUESTION Are molecular pathways reflecting the biology of small for gestational age (SGA) neonates preserved in umbilical cord-derived mesenchymal stem cells (MSCs)? SUMMARY ANSWER MSCs from SGA newborns were found to express an altered EGR-1-dependent gene network involved in the regulation of cell proliferation and oxidative stress. WHAT IS KNOWN ALREADY Individuals with suboptimal intrauterine development are at greater risk of metabolic diseases such as type II diabetes, obesity and cardiovascular disease. STUDY DESIGN, SIZE, DURATION Umbilical cords (n = 283) from the GUSTO (growing up in Singapore towards he...
Source: Human Reproduction - September 15, 2014 Category: Reproduction Medicine Authors: Sukarieh, R., Joseph, R., Leow, S. C., Li, Y., Loffler, M., Aris, I. M., Tan, J. H., Teh, A. L., Chen, L., Holbrook, J. D., Ng, K. L., Lee, Y. S., Chong, Y. S., Summers, S. A., Gluckman, P. D., Stunkel, W. Tags: Reproductive biology Source Type: research

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