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The UPR mediates fibrogenesis and collagen I secretion through regulating TANGO1
Conclusion: Loss of TANGO1 leads to procollagen I retention in the ER which promotes UPR‐mediated HSC apoptosis. TANGO1 regulation during HSC activation occurs through a UPR dependent mechanism that requires the transcription factor XBP‐1. Finally, TANGO1 is critical for fibrogenesis through mediating HSC homeostasis. Our work reveals a unique role for TANGO1 and the UPR in facilitating collagen I secretion and fibrogenesis. This article is protected by copyright. All rights reserved.
Source: Hepatology - November 4, 2016 Category: Internal Medicine Authors: Jessica L Maiers, Enis Kostallari, Malek Mushref, Thiago M de Assuncao, Haiyang Li, Robert C Huebert, Sheng Cao, Harmeet Malhi, Vijay H Shah Tags: Liver Biology and Pathobiology Source Type: research

Specific hepatic delivery of procollagen α1(I) siRNA in lipid‐like nanoparticles resolves liver fibrosis
Conclusion: The data reported in the present study extensively show that LNP‐siCol1a1 specifically reduce total hepatic collagen content without detectable side effects, potentially qualifying as a therapy for fibrotic liver diseases. This article is protected by copyright. All rights reserved.
Source: Hepatology - June 10, 2015 Category: Internal Medicine Authors: Carolina Jiménez Calvente, Alfica Sehgal, Yury Popov, Yong Ook Kim, Victor Zevallos, Ugur Sahin, Mustafa Diken, Detlef Schuppan Tags: Liver Failure, Cirrhosis and Portal Hypertension Source Type: research