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Protein Disulfide Isomerase Inhibition Impairs Keap1/Nrf2 Signaling and Mitochondrial Function and Induces Apoptosis in Renal Proximal Tubular Cells.
Abstract Renal proximal tubular apoptosis plays a critical role in kidney health and disease. However, cellular molecules that trigger renal apoptosis remain elusive. Here, we evaluated the effect of inhibiting protein disulfide isomerase (PDI), a critical thioredoxin chaperone protein, on apoptosis, and the underlying mechanisms in human renal proximal tubular (HK2) cells. HK2 cells were transfected with PDI specific siRNA in the absence and presence of an antioxidant tempol. PDI siRNA transfection resulted in a decrease of ~70% in PDI protein expression and enzyme activity. PDI inhibition increased caspase-3 act...
Source: Am J Physiol Renal P... - August 23, 2020 Category: Urology & Nephrology Authors: Pokkunuri ID, Lokhandwala MF, Banday AA Tags: Am J Physiol Renal Physiol Source Type: research

Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification
Conclusion: Silencing of SHMT1 promotes osteo-/chondrogenic signaling in VSMCs, at least in part, by inducing cellular oxidative stress. It thus aggravates phosphate-induced calcification of VSMCs. The present findings support a regulatory role of SHMT1 in vascular calcification during conditions of hyperphosphatemia such as chronic kidney disease.Kidney Blood Press Res 2018;43:1212 –1221
Source: Kidney and Blood Pressure Research - August 2, 2018 Category: Urology & Nephrology Source Type: research

The orally active pterocarpanquinone LQB ‐118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress
ConclusionLQB‐118 is a developing and orally active pterocarpanquinone agent that effectively kills PCa cells through quinone reduction and ROS generation. The inhibition SOD1 expression enhances LQB‐118 activity, presumably by impairing the cellular antioxidant response.
Source: The Prostate - November 6, 2017 Category: Urology & Nephrology Authors: Thiago Martino, Tarana A. Kudrolli, Binod Kumar, Isis Salviano, Andr é Mencalha, Marsen Garcia P. Coelho, Graça Justo, Paulo R. Ribeiro Costa, Kátia C. Carvalho Sabino, Shawn E. Lupold Tags: ORIGINAL ARTICLE Source Type: research