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STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) leads to renal failure. The hallmark of ADPKD is increased epithelial proliferation, which has been proposed to be due to atypical signaling including abnormal JAK-STAT activity. However, the relative contribution of JAK-STAT family members in promoting proliferation in ADPKD is unknown. Here, we present siRNA JAK-STAT –focused screens discovering a previously unknown proliferative role for multiple JAK-STAT components (including STAT1, STAT2, STAT4, STAT5a, and STAT5b).
Source: Kidney International - January 15, 2017 Category: Urology & Nephrology Authors: Maria Fragiadaki, Morgane Lannoy, Madeleine Themanns, Barbara Maurer, Wouter N. Leonhard, Dorien J.M. Peters, Richard Moriggl, Albert C.M. Ong Tags: Basic Research Source Type: research

Blockade of interleukin‐8 receptor signalling inhibits cyst development in vitro, via suppression of cell proliferation in autosomal polycystic kidney disease
ConclusionThese results suggest that IL‐8 and its signalling molecules could be new biomarkers and a therapeutic target of ADPKD.
Source: Nephrology - July 25, 2014 Category: Urology & Nephrology Authors: Eun Ji Lee, Seon Ah Song, Hyo Won Mun, Kyung Hyun Yoo, Soo Young Choi, Eun Young Park, Jong Hoon Park Tags: Original Article Source Type: research

Blockade of IL‐8 receptor signaling inhibits cyst development in vitro, via suppression of cell proliferation in Autosomal Polycystic Kidney Disease
ConclusionThese results suggest that IL‐8 and its signaling molecules could be new biomarkers and a therapeutic target of ADPKD.
Source: Nephrology - April 1, 2014 Category: Urology & Nephrology Authors: Eun Ji Lee, Seon Ah Song, Hyo Won Mun, Kyung Hyun Yoo, Soo Young Choi, Eun Young Park, Jong Hoon Park Tags: Original Article Source Type: research