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MicroRNAs from the parasitic plant Cuscuta campestris target host messenger RNAs
hael J. Axtell Dodders (Cuscuta spp.) are obligate parasitic plants that obtain water and nutrients from the stems of host plants via specialized feeding structures called haustoria. Dodder haustoria facilitate bidirectional movement of viruses, proteins and mRNAs between host and parasite, but the functional effects of these movements are not known. Here we show that Cuscuta campestris haustoria accumulate high levels of many novel microRNAs (miRNAs) while parasitizing Arabidopsis thaliana. Many of these miRNAs are 22 nucleotides in length. Plant miRNAs of this length are uncommon, and are associated with amplification...
Source: Nature - January 3, 2018 Category: Research Authors: Saima Shahid Gunjune Kim Nathan R. Johnson Eric Wafula Feng Wang Ceyda Coruh Vivian Bernal-Galeano Tamia Phifer Claude W. dePamphilis James H. Westwood Michael J. Axtell Tags: Letter Source Type: research

Important factors mediates the adhesion of aspergillus fumigatus to alveolar epithelial cells with E-cadherin.
In conclusion, E-cadherin is a receptor for adhesion of A. fumigatus blastospores in epithelial cells. This may open a new approach to treat this fungal infection. PMID: 27347350 [PubMed]
Source: American Journal of Translational Research - June 29, 2016 Category: Research Tags: Am J Transl Res Source Type: research