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Specialty: Research
Source: Medical Science Monitor
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Total 166 results found since Jan 2013.
Post-Treatment Sevoflurane Protects Against Hypoxic-Ischemic Brain Injury in Neonatal Rats by Downregulating Histone Methyltransferase G9a and Upregulating Nuclear Factor Erythroid 2-Related Factor 2 (NRF2)
CONCLUSIONS Sevoflurane post-treatment promotes NRF2 expression by inhibiting G9a and H3K9me2, thus alleviating HIBI in neonatal rats.PMID:34059615 | DOI:10.12659/MSM.930042
Source: Medical Science Monitor - June 1, 2021 Category: Research Authors: HuaiMing Wang YiQuan Xu Shuying Zhu XueMing Li HongWei Zhang Source Type: research
Expression of DUSP12 Reduces Lung Vascular Endothelial Cell Damage in a Murine Model of Lipopolysaccharide-Induced Acute Lung Injury via the Apoptosis Signal-Regulating Kinase 1 (ASK1)-Jun N-Terminal Kinase Activation (JNK) Pathway
CONCLUSIONS Our data demonstrated that DUSP12 suppressed MLEC injury in response to LPS insult by regulating the ASK1/JNK pathway.PMID:33811209 | DOI:10.12659/MSM.930429
Source: Medical Science Monitor - April 3, 2021 Category: Research Authors: Zhao Hui Huang Jie Guo-Hua Fan Source Type: research
Long Non-Coding RNA Nuclear-Enriched Abundant Transcript 1 (NEAT1) Represses Proliferation of Trophoblast Cells in Rats with Preeclampsia via the MicroRNA-373/FLT1 Axis.
CONCLUSIONS NEAT1 may contribute to PE development by regulating trophoblast cell proliferation and apoptosis. These findings may provide a new perspective for understanding the etiology and pathogenesis of PE.
PMID: 33093438 [PubMed - in process]
Source: Medical Science Monitor - October 24, 2020 Category: Research Tags: Med Sci Monit Source Type: research
Effect of Sleeve Gastrectomy on Glycometabolism via Forkhead Box O1 (FoxO1)/Lipocalin-2 (LCN2) Pathway.
CONCLUSIONS These results suggest that the FOXO1/LCN2 signaling pathway participates in the anti-diabetic effect of SG.
PMID: 32845875 [PubMed - in process]
Source: Medical Science Monitor - August 29, 2020 Category: Research Tags: Med Sci Monit Source Type: research
Role of Sirtuin-1 in Neonatal Hypoxic-Ischemic Encephalopathy and Its Underlying Mechanism.
CONCLUSIONS Our findings revealed that SIRT1 may be a novel and promising therapy target for HIE treatment.
PMID: 32826847 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - August 23, 2020 Category: Research Tags: Med Sci Monit Source Type: research
Mixed Lineage Kinase Domain-Like Protein Promotes Human Monocyte Cell Adhesion to Human Umbilical Vein Endothelial Cells Via Upregulation of Intercellular Adhesion Molecule-1 Expression.
CONCLUSIONS MLKL can promote THP-1 cell adhesion to HUVECs through up-regulation of ICAM-1 expression in HUVECs. Thus, MLKL might be a useful target for reducing adhesion of monocytes to endothelial cells and atherosclerosis.
PMID: 32788571 [PubMed - in process]
Source: Medical Science Monitor - August 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research
Silencing of Long Non-Coding RNA (LncRNA) Non-Coding RNA Activated by DNA Damage (NORAD) Inhibits Proliferation, Invasion, Migration, and Promotes Apoptosis of Glioma Cells via Downregulating the Expression of AKR1B1.
CONCLUSIONS These findings demonstrated that NORAD silencing suppressed proliferation, invasion, and migration and boosted apoptosis of glioma cells via downregulating the AKR1B1 expression, which may provide a potential therapeutic target for glioma treatment.
PMID: 32778640 [PubMed - in process]
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research
Myoglobin Mediates Autophagy of NRK-52E in Rat Renal Tubular Epithelial Cells Via the Pink1/Parkin Signaling Pathway.
CONCLUSIONS Myoglobin mediates the autophagy of NRK-52E in rat renal tubular epithelial cells via the Pink1/Parkin signaling pathway.
PMID: 32697768 [PubMed - in process]
Source: Medical Science Monitor - July 23, 2020 Category: Research Tags: Med Sci Monit Source Type: research
Regulation of Keap-1/Nrf2 Signaling Pathway Is Activated by Oxidative Stress in Patients with Premature Rupture of Membranes.
CONCLUSIONS We found that increased ROS levels and decreased antioxidant enzymes in the PPROM and FPROM patients compared with the control group.
PMID: 32589628 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - June 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research
The Effects of Interleukin-33 (IL-33) on Osteosarcoma Cell Viability, Apoptosis, and Epithelial-Mesenchymal Transition are Mediated Through the PI3K/AKT Pathway.
CONCLUSIONS IL-33 was highly expressed in human osteosarcoma cells. Down-regulation of IL-33 reduced cell viability and EMT of osteosarcoma cells, and induced cell apoptosis through activation of the PI3K/AKT signaling pathway.
PMID: 32312946 [PubMed - in process]
Source: Medical Science Monitor - April 23, 2020 Category: Research Tags: Med Sci Monit Source Type: research
The Effects of the Transforming Growth Factor- β1 (TGF-β1) Signaling Pathway on Cell Proliferation and Cell Migration are Mediated by Ubiquitin Specific Protease 4 (USP4) in Hypertrophic Scar Tissue and Primary Fibroblast Cultures.
CONCLUSIONS USP4 regulated the proliferation, migration, and apoptosis of hypertrophic scar fibroblasts by regulating the TGF-ß1 signaling pathway.
PMID: 32308208 [PubMed - in process]
Source: Medical Science Monitor - April 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research
Effect of Aldosterone on Senescence and Proliferation Inhibition of Endothelial Progenitor Cells Induced by Sirtuin 1 (SIRT1) in Pulmonary Arterial Hypertension.
CONCLUSIONS ALDO promoted EPCs senescence and inhibited EPCs proliferation by downregulating SIRT1, which regulates the p53/p21 pathway, thus promoting PAH.
PMID: 32303670 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - April 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research
Long Non-Coding RNA MACC1-AS1 Is Involved in Distant Recurrence of Hepatocellular Carcinoma After Surgical Resection.
CONCLUSIONS MACC1-AS1 is involved in the distant recurrence of HCC, and its actions are possibly mediated by TGF-ß1.
PMID: 32267834 [PubMed - in process]
Source: Medical Science Monitor - April 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research
Long Non-Coding RNA (lncRNA) SNHG5 Participates in Vertical Sleeve Gastrectomy for Type II Diabetes Mellitus by Regulating TGR5.
CONCLUSIONS By downregulating expression of the SNHG5 gene and then altering expression of the TGR5 gene, the damage to colorectal cells induced by high glucose was alleviated. This may be one of the mechanisms underlying the effect of sleeve gastric surgery in treatment of diabetes mellitus.
PMID: 32242546 [PubMed - in process]
Source: Medical Science Monitor - April 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research
