• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3
CONCLUSIONS: These data in mice implicate a role for HAS3 in long-term effects of CPAP in the developing airway in the context of preterm birth and CPAP therapy.IMPACT: Neonatal CPAP increases airway smooth muscle and epithelial HAS3 expression in mice. CPAP-induced airway hyper-reactivity is modulated by HAS3. These data enhance our understanding of the role mechanical forces play on lung development. These data are a significance step toward understanding CPAP effects on developing airway. These data may impact clinical recognition of the ways that CPAP may contribute to wheezing disorders of former preterm infants.PMID:...
Source: Pediatric Research - November 9, 2021 Category: Pediatrics Authors: Catherine A Mayer Abhrajit Ganguly Aubrey Mayer Christina M Pabelick Y S Prakash Vince C Hascall Ron J Midura Valbona Cali Christopher A Flask Bernadette O Erokwu Richard J Martin Peter M MacFarlane Source Type: research

Novel targeted therapy for neuroblastoma: Silencing the MXD3 gene using siRNA.
CONCLUSIONS: These results indicate that MXD3 is a potential new target and MXD3 siRNA nanocomplexes are a novel therapeutic approach for neuroblastoma.Pediatric Research accepted article preview online, 18 April 2017. doi:10.1038/pr.2017.74. PMID: 28419087 [PubMed - as supplied by publisher]
Source: Pediatric Research - April 18, 2017 Category: Pediatrics Authors: Duong C, Yoshida S, Chen C, Barisone G, Diaz E, Li Y, Beckett L, Chung J, Antony R, Nolta J, Nitin N, Satake N Tags: Pediatr Res Source Type: research