CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3

CONCLUSIONS: These data in mice implicate a role for HAS3 in long-term effects of CPAP in the developing airway in the context of preterm birth and CPAP therapy.IMPACT: Neonatal CPAP increases airway smooth muscle and epithelial HAS3 expression in mice. CPAP-induced airway hyper-reactivity is modulated by HAS3. These data enhance our understanding of the role mechanical forces play on lung development. These data are a significance step toward understanding CPAP effects on developing airway. These data may impact clinical recognition of the ways that CPAP may contribute to wheezing disorders of former preterm infants.PMID:34750521 | DOI:10.1038/s41390-021-01695-0

Source: Pediatric Research - November 9, 2021 Category: Pediatrics Authors: Catherine A Mayer Abhrajit Ganguly Aubrey Mayer Christina M Pabelick Y S Prakash Vince C Hascall Ron J Midura Valbona Cali Christopher A Flask Bernadette O Erokwu Richard J Martin Peter M MacFarlane Source Type: research