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CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3
CONCLUSIONS: These data in mice implicate a role for HAS3 in long-term effects of CPAP in the developing airway in the context of preterm birth and CPAP therapy.IMPACT: Neonatal CPAP increases airway smooth muscle and epithelial HAS3 expression in mice. CPAP-induced airway hyper-reactivity is modulated by HAS3. These data enhance our understanding of the role mechanical forces play on lung development. These data are a significance step toward understanding CPAP effects on developing airway. These data may impact clinical recognition of the ways that CPAP may contribute to wheezing disorders of former preterm infants.PMID:...
Source: Pediatric Research - November 9, 2021 Category: Pediatrics Authors: Catherine A Mayer Abhrajit Ganguly Aubrey Mayer Christina M Pabelick Y S Prakash Vince C Hascall Ron J Midura Valbona Cali Christopher A Flask Bernadette O Erokwu Richard J Martin Peter M MacFarlane Source Type: research

Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice
CONCLUSIONS: These data implicate CaSR in CPAP effects on airway function with implications for wheezing in former preterm infants.IMPACT: Neonatal CPAP increases airway reactivity to bronchoconstrictor agonist. CPAP increases smooth muscle expression of the extracellular calcium-sensing receptor (CaSR). Inhibition or absence of CaSR blunts CPAP effects on contractility. These data suggest a causal/contributory role for CaSR in stretch effects on the developing airway. These data may impact clinical recognition of the ways that CPAP may contribute to wheezing disorders of former preterm infants.PMID:33958714 | DOI:10.1038/s41390-021-01540-4
Source: Pediatric Research - May 7, 2021 Category: Pediatrics Authors: Catherine A Mayer Benjamin Roos Jacob Teske Natalya Wells Richard J Martin Wenhan Chang Christina M Pabelick Y S Prakash Peter M MacFarlane Source Type: research

Novel targeted therapy for neuroblastoma: Silencing the MXD3 gene using siRNA.
CONCLUSIONS: These results indicate that MXD3 is a potential new target and MXD3 siRNA nanocomplexes are a novel therapeutic approach for neuroblastoma.Pediatric Research accepted article preview online, 18 April 2017. doi:10.1038/pr.2017.74. PMID: 28419087 [PubMed - as supplied by publisher]
Source: Pediatric Research - April 18, 2017 Category: Pediatrics Authors: Duong C, Yoshida S, Chen C, Barisone G, Diaz E, Li Y, Beckett L, Chung J, Antony R, Nolta J, Nitin N, Satake N Tags: Pediatr Res Source Type: research

Mitogen-activated protein kinase phosphatase-1 prevents lipopolysaccharide-induced apoptosis in immature rat intestinal epithelial cells.
CONCLUSION: Our results demonstrate that MKP-1 has a central role in preventing inflammation-induced apoptosis in rIEC-6 enterocytes.Pediatric Research (2015); doi:10.1038/pr.2015.88. PMID: 25950450 [PubMed - as supplied by publisher]
Source: Pediatric Research - May 7, 2015 Category: Pediatrics Authors: Talavera MM, Kralik N, Jin Y, Chen B, Liu Y, Nelin LD Tags: Pediatr Res Source Type: research

Integrin-linked Kinase Mediates CTGF-induced Epithelial to Mesenchymal Transition in Alveolar Type II Epithelial Cells.
ConclusionsOverexpression of CTGF induces EMT in mouse primary AT II cells and this is mediated by ILK.Pediatric Research (2015); doi:10.1038/pr.2015.8. PMID: 25580742 [PubMed - as supplied by publisher]
Source: Pediatric Research - January 12, 2015 Category: Pediatrics Authors: Shafieian M, Chen S, Wu S Tags: Pediatr Res Source Type: research

Altered Pulmonary Artery Endothelial-Smooth Muscle Cell Interactions in Experimental Congenital Diaphragmatic Hernia.
ConclusionsPAEC dysfunction in experimental CDH increases SMC proliferation via ET-1 induced ROS production by PAEC.Pediatric Research (2015); doi:10.1038/pr.2015.13. PMID: 25580737 [PubMed - as supplied by publisher]
Source: Pediatric Research - January 12, 2015 Category: Pediatrics Authors: Acker SN, Seedorf GJ, Abman SH, Nozik-Grayck E, Kuhn K, Partrick DA, Gien J Tags: Pediatr Res Source Type: research