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Total 12 results found since Jan 2013.
Photoreceptor cell calcium dysregulation and calpain activation promote pathogenic photoreceptor oxidative stress and inflammation in prodromal diabetic retinopathy
In this study, we test the hypothesis that diabetes promotes a greater than normal cytosolic calcium level in rod cells that activates a Ca2+-sensitive protease, calpain, resulting in oxidative stress and inflammation, two pathogenic factors of early diabetic retinopathy (DR). Nondiabetic and 2-months diabetic C57Bl/6J and calpain1 knockout (Capn1-/-) mice were studied; subgroups were treated with a calpain inhibitor (CI). Ca2+ content was measured in photoreceptors using Fura-2. Retinal calpain expression was studied by qTR-PCR and immunohistochemistry. Superoxide and expression of inflammatory proteins were measured usin...
Source: Am J Pathol - July 2, 2021 Category: Pathology Authors: Aicha Saadane Yunpeng Du Wallace B Thoreson Masaru Miyagi Emma M Lessieur Jianying Kiser Xiangyi Wen Bruce A Berkowitz Timothy S Kern Source Type: research
