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Phloretin enhances autophagy by impairing AKT activation and inducing JNK-Beclin-1 pathway activation
In conclusion, our results suggest that the AKT/mTOR pathway and JNK-mediated Beclin-1 expression are involved in phloretin-induced autophagy. Phloretin can be used to protect neurons during phloretin treatment of glioblastoma.PMID:35878674 | DOI:10.1016/j.yexmp.2022.104814
Source: Experimental and Molecular Pathology - July 25, 2022 Category: Pathology Authors: Chenghe Fan Yilin Zhang Yu Tian Xinyu Zhao Junfang Teng Source Type: research

Oxidative stress activated by Keap-1/Nrf2 signaling pathway in pathogenesis of preeclampsia.
In this study, we found that under hypoxia/reoxygenation conditions, the activities of oxidative stress-related enzymes (CAT, GSH-Px, SOD) in HTR8/SVneo cells were significantly lower than those before treatment (P<0.01). The activities of CAT, GSH-Px and SOD in HTR8/SVneo cells in siRNA+H/R group decreased significantly (P<0.01), which indicated the important defensive effect of Keap1/Nrf2 pathway in oxidative stress. Compared with Nrf2 siRNA+H/R group, Si-NC+H/R group had CAT, GSH-Px and SOD activities decreasing, which were similar to those in the H/R group. Moreover, the activities of oxidative stress-related act...
Source: International Journal of Clinical and Experimental Pathology - April 10, 2020 Category: Pathology Authors: Feng H, Wang L, Zhang G, Zhang Z, Guo W Tags: Int J Clin Exp Pathol Source Type: research