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Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage
ConclusionOur results suggested that low expression of HDAC2 under SeD condition increased ROS content by decreasing FOXO3A in chondrocytes, which led to the activation of NF- κB pathway and ECM homeostasis imbalance.
Source: Journal of Bone and Mineral Metabolism - September 26, 2022 Category: Orthopaedics Source Type: research

LncPVT1 promotes cartilage degradation in diabetic OA mice by downregulating miR-146a and activating TGF- β/SMAD4 signaling
ConclusionsOur results demonstrate LncRNA PVT1 is involved in cartilage degradation in diabetic OA and correlated with disease severity. Efficiency of ad-siRNA-PVT1 in controlling joint inflammation in diabetic OA mice is associated with the suppression of the expression of miR-146a, pro-inflammatory cytokines and activation of TGF- β/SMAD4 pathway.
Source: Journal of Bone and Mineral Metabolism - February 10, 2021 Category: Orthopaedics Source Type: research

Long non-coding RNA PCAT-1 regulates apoptosis of chondrocytes in osteoarthritis by sponging miR-27b-3p
ConclusionsBased on the comparisons and analysis, we could conclude that lncRNA PCAT-1 regulated the apoptosis of chondrocytes through sponging miR-27b-3p in OA. PCAT-1 has potential values to act as a new therapeutic target for OA patients.
Source: Journal of Bone and Mineral Metabolism - August 7, 2020 Category: Orthopaedics Source Type: research

MiR-203 regulates estrogen receptor α and cartilage degradation in IL-1β-stimulated chondrocytes
ConclusionsMiR-203 is critical in the onset and progression of OA, at least in part, caused by estrogen deficiency and ER α instability in OA patients, providing a novel therapeutic target for the treatment of OA.
Source: Journal of Bone and Mineral Metabolism - December 31, 2019 Category: Orthopaedics Source Type: research

Effect of RAB31 silencing on osteosarcoma cell proliferation and migration through the Hedgehog signaling pathway
In this study, we aimed to explore the functions of Ras-related protein Rab-31 (RAB31) in OS-cell proliferation, migration, and invasion as well as its roles in the Hedgehog signaling pathway for better understanding of the mechanism. To assess the detailed regulatory mechanism of RAB31 silencing on OS, both RT-qPCR and Western blot analysis were employed to evaluate the expressions of RAB31 as well as the Hedgehog signaling pathway-related genes. Besides, we also investigated the effects of silenced RAB31 both in vitro and in vivo. First, we found that in OS tissues, both mRNA and protein expressions of RAB31 and PCNA had...
Source: Journal of Bone and Mineral Metabolism - November 23, 2018 Category: Orthopaedics Source Type: research

PEG10 counteracts signaling pathways of TGF- β and BMP to regulate growth, motility and invasion of SW1353 chondrosarcoma cells
AbstractRecently, we reported highly active transforming growth factor (TGF)- β and bone morphogenetic protein (BMP) signaling in human chondrosarcoma samples and concurrent downregulation of paternally expressed gene 10 (PEG10). PEG10 expression was suppressed by TGF- β signaling, and PEG10 interfered with the TGF-β and BMP-SMAD pathways in chondrosarcoma cells. However, the roles of PEG10 in bone tumors, including chondrosarcoma, remain unknown. Here, we report that PEG10 promotes SW1353 chondrosarcoma cell growth by preventing TGF-β1-mediated suppression. In contrast, PEG10 knockdown augments the TGF-β1-induced mot...
Source: Journal of Bone and Mineral Metabolism - August 9, 2018 Category: Orthopaedics Source Type: research

Zinc-finger transcription factor Odd - skipped related 1 regulates cranial bone formation
AbstractKnowledge of the molecular mechanisms of bone formation has been advanced by novel findings related to genetic control.Odd-skipped related 1 (Osr1) is known to play important roles in embryonic, heart, and urogenital development. To elucidate the in vivo function ofOsr1 in bone formation, we generated transgenic mice overexpressing full-lengthOsr1 under control of its 2.8-kb promoter, which were smaller than their wild-type littermates. Notably, abnormalities in the skull ofOsr1 transgenic mice were revealed by analysis of X-ray, skeletal preparation, and morphological findings, including round skull and cranial dy...
Source: Journal of Bone and Mineral Metabolism - December 12, 2017 Category: Orthopaedics Source Type: research

Role of plasminogen activator inhibitor-1 in glucocorticoid-induced muscle change in mice
In conclusion, our data suggest that paracrine PAI-1 is involved in GC-induced muscle wasting through the enhancement of muscle degradation in mice.
Source: Journal of Bone and Mineral Metabolism - March 19, 2017 Category: Orthopaedics Source Type: research