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Evaluation of Adenovirus-Mediated Down-Regulation of Connective Tissue Growth Factor on Postoperative Wound Healing After Experimental Glaucoma Surgery.
CONCLUSIONS: Down-regulation of CTGF is effective in inhibiting postoperative scarring in vivo. This suggests that RNAi with CTGF siRNA may potentially pave the road for a novel therapeutic strategy to improve glaucoma surgery results. PMID: 26554857 [PubMed - as supplied by publisher]
Source: Current Eye Research - November 10, 2015 Category: Opthalmology Authors: Lim DH, Kim TE, Kee C Tags: Curr Eye Res Source Type: research

Role of PKC{alpha} Activation of Src, PI-3K/AKT, and ERK in EGF-Stimulated Proliferation of Rat and Human Conjunctival Goblet Cells Cornea
Conclusions. We found that EGF activates a major pathway to stimulate goblet cell proliferation. This pathway consists of induction of phospholipase C (PLC) to activate PKCα. Active PKCα phosphorylates Src to induce PI-3K to phosphorylate AKT that subsequently activates the ERK1/2 cascade to stimulate goblet cell proliferation.
Source: Investigative Ophthalmology - August 21, 2013 Category: Opthalmology Authors: Li, D., Shatos, M. A., Hodges, R. R., Dartt, D. A. Tags: Cornea Source Type: research

ERK5 Regulates Glucose-Induced Increased Fibronectin Production in the Endothelial Cells and in the Retina in Diabetes Retina
Conclusions. Our experiments demonstrated a novel mechanism of glucose-induced increased FN production in diabetic retinopathy, which is mediated through decreased ERK5 signaling.
Source: Investigative Ophthalmology - December 19, 2012 Category: Opthalmology Authors: Wu, Y., Feng, B., Chen, S., Chakrabarti, S. Tags: Retina Source Type: research