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Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review.
Authors: Lanza M, Benincasa G, Costa D, Napoli C Abstract Network medicine is a molecular-bioinformatic approach analyzing gene-gene interactions that can perturb the human interactome. This review focuses on epigenetic changes involved in several ocular diseases, such as DNA methylation, histone and nonhistone post-translational modifications, and noncoding RNA regulators. Although changes in aberrant DNA methylation play a major role in the pathogenesis of most ocular diseases, histone modifications are seldom investigated. Hypermethylation in TGM-2 and hypomethylation in MMP-2/CD24 promoter genes may play a cruc...
Source: Journal of Ophthalmology - January 25, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Enhanced expression of son of sevenless homolog 1 is predictive of poor prognosis in uveal malignant melanoma patients.
CONCLUSION: Our data demonstrated that SOS1 might play a facilitating role in M23 cell growth and motility by regulating the MAPK signaling pathway. Furthermore, the data suggested that SOS1 may serve as an UM predictor of prognosis as well as a therapeutic target. PMID: 30714452 [PubMed - as supplied by publisher]
Source: Ophthalmic Genetics - February 6, 2019 Category: Opthalmology Tags: Ophthalmic Genet Source Type: research

Inhibition of Polo-Like Kinase 1 Promotes Hyperthermia Sensitivity via Inactivation of Heat Shock Transcription Factor 1 in Human Retinoblastoma Cells New Developments
Conclusions. Polo-like kinase 1 inhibition may attenuate the thermoresistance of HT through the inactivation of HSF1 concomitant with reductions in HSPs and BAG3. The combination of PLK1 inhibition and HT may become an option for HT therapy in patients with retinoblastoma.
Source: Investigative Ophthalmology - December 23, 2013 Category: Opthalmology Authors: Yunoki, T., Tabuchi, Y., Hayashi, A., Kondo, T. Tags: New Developments Source Type: research

Novel Quinic Acid Derivative KZ-41 Prevents Retinal Endothelial Cell Apoptosis Without Inhibiting Retinoblastoma Cell Death Through p38 Signaling Translational
Conclusions. KZ-41 protects REC against melphalan-induced upregulation of ICAM-1 and apoptosis through p38 MAPK–dependent pathways.
Source: Investigative Ophthalmology - September 3, 2013 Category: Opthalmology Authors: Zhang, Q., Jiang, Y., Toutounchian, J., Wilson, M. W., Morales-Tirado, V., Miller, D. D., Yates, C. R., Steinle, J. J. Tags: Translational Source Type: research

MicroRNA-124a Is Epigenetically Regulated and Acts as a Tumor Suppressor by Controlling Multiple Targets in Uveal Melanoma Biochemistry and Molecular Biology
Conclusions. Our results demonstrated that miR-124a could function as a potent tumor suppressor by regulation of multiple targets, and was epigenetically silenced in the development of uveal melanoma.
Source: Investigative Ophthalmology - March 27, 2013 Category: Opthalmology Authors: Chen, X., He, D., Dong, X. D., Dong, F., Wang, J., Wang, L., Tang, J., Hu, D.-N., Yan, D., Tu, L. Tags: Biochemistry and Molecular Biology Source Type: research