• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Ferritin was involved in interleukin-17A enhanced osteogenesis through autophagy activation
In conclusion, IL-17A induced ferritin expression in osteoblasts, which further enhanced osteogenic differentiation via autophagy activation. These findings may provide further insight into the role of IL-17A in osteoblast differentiation and demonstrate ferritin as a potential target in modulating alveolar bone homeostasis.PMID:37713787 | DOI:10.1016/j.intimp.2023.110916
Source: International Immunopharmacology - September 15, 2023 Category: Allergy & Immunology Authors: Wenlin Yuan Yuting Yang Yingming Wei Xufei Yu Jiaqi Bao Jiahui Zhong Zhongxiu Wang Lili Chen Source Type: research

Ferroptosis is involved in PM2.5-induced acute nasal epithelial injury via AMPK-mediated autophagy
Int Immunopharmacol. 2023 Jan 4;115:109658. doi: 10.1016/j.intimp.2022.109658. Online ahead of print.ABSTRACTPM2.5 is one of the main harmful environmental pollutants and can damage nasal epithelial carriers to worsen allergic rhinitis. Ferroptosis is a novel form of regulated cell death with iron-dependent lipid peroxidation. However, whether ferroptosis is involved in PM2.5-induced nasal epithelial injury has not been elucidated. To verify the vital role of ferroptosis in PM2.5-induced nasal epithelial injury and further explore the potential mechanism, we detected intracellular iron content, ROS release and lipid peroxi...
Source: International Immunopharmacology - January 6, 2023 Category: Allergy & Immunology Authors: Wenjing Gu Tianhua Hou Hongwei Zhou Laiyu Zhu Wei Zhu Yusheng Wang Source Type: research

Simultaneous blockade of TIGIT and HIF-1 α induces synergistic anti-tumor effect and decreases the growth and development of cancer cells
CONCLUSIONS: Present data suggest the combination treatment of TIGIT and HIF-1α as a novel treatment strategy against colorectal and breast cancer, but more researches are required to realize the complete role of TIGIT and HIF-1α inside the TME.PMID:34710844 | DOI:10.1016/j.intimp.2021.108288
Source: International Immunopharmacology - October 28, 2021 Category: Allergy & Immunology Authors: Mehrdad Fathi Simin Bahmanpour Asal Barshidi Hossein Rasouli Fariba Karoon Kiani Armin Mahmoud Salehi Khesht Sepideh Izadi Bentolhoda Rashidi Shiva Kermanpour Roya Mokhtarian Vahid Karpisheh Hadi Hassannia Hamed Mohammadi Ali Jalili Farhad Jadidi-Niaragh Source Type: research

Identification and functional characterization of natural resistance-associated macrophage protein 2 from sea cucumber Apostichopus japonicus.
In this study, a unique echinoderm Nramp2 was identified from sea cucumber Apostichopus japonicus (designated as AjNramp2). The cDNA sequence of AjNramp2 was 2360 bp, with a putative open reading frame of 1713 bp, encoding a typical Nramp domain containing protein with 570 amino acid residues. Structural analysis revealed that AjNramp2 consisted of highly conserved helix regions similar with the human Nramp2. Spatial expression analysis revealed that AjNramp2 was ubiquitously expressed in all examined tissues, with the highest level found in the intestine. Immunohistochemistry assay showed that AjNramp2 was mainly located ...
Source: Developmental and Comparative Immunology - August 21, 2020 Category: Allergy & Immunology Authors: Huang B, Lv Z, Li Y, Li C Tags: Dev Comp Immunol Source Type: research

TonEBP Suppresses the HO-1 Gene by Blocking Recruitment of Nrf2 to Its Promoter
Discussion Dynamic changes in the functional phenotype of macrophages are associated with pathogenesis of inflammatory diseases (5–7). TonEBP primes macrophages toward an M1 phenotype, which has pro-inflammatory properties. TonEBP does this by promoting expression of pro-inflammatory genes via interaction with NF-κB (36) and by binding directly to the promoter (37, 64). In addition, TonEBP suppresses expression of the anti-inflammatory cytokine IL-10 by limiting chromatin access to the promoter (37). The pro-inflammatory function of TonEBP suggests that inhibiting its expression or activation could suppres...
Source: Frontiers in Immunology - April 17, 2019 Category: Allergy & Immunology Source Type: research