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MALAT1 Improves Functional Recovery after Traumatic Brain Injury through Promoting Angiogenesis in Experimental Mice
Brain Res. 2021 Nov 19:147731. doi: 10.1016/j.brainres.2021.147731. Online ahead of print.ABSTRACTAs a highly evolutionary conserved lncRNA, MALAT1 was first demonstrated to associate with metastasis of lung tumor by promoting angiogenesis. Activated vasculature was recently indicated to assist neurogenesis by secreting neurotrophic factor Ang1 (Angiopoietin-1). The purpose of this study is to investigate the potential role of MALAT1 in angiogenesis following traumatic brain injury (TBI). Adult male mice were subjected to controlled cortical impact (CCI) and brain microvacular endothelial cells were exposed to oxygen-gluco...
Source: Brain Research - November 22, 2021 Category: Neurology Authors: Han Liu Zhaosheng Wei Xiaochuan Sun Zhigang Wang Source Type: research