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MiR-125b-1-3p Exerts Antitumor Functions in Lung Carcinoma Cells by Targeting S1PR1.
Conclusion: Our results suggest that miR-125b-1-3p exerts antitumor functions in NSCLC cells by targeting S1PR1. PMID: 30082521 [PubMed - in process]
Source: Chinese Medical Journal - August 9, 2018 Category: General Medicine Authors: Zhang X, Liu Y, Huang WC, Zheng LC Tags: Chin Med J (Engl) Source Type: research

Curcumin Inhibits Lipopolysaccharide-Induced Mucin 5AC Hypersecretion and Airway Inflammation via Nuclear Factor Erythroid 2-Related Factor 2.
Conclusion: CUR inhibits LPS-induced airway mucus hypersecretion and inflammation through activation of Nrf2 possibly. PMID: 29998888 [PubMed - in process]
Source: Chinese Medical Journal - July 14, 2018 Category: General Medicine Authors: Lin XP, Xue C, Zhang JM, Wu WJ, Chen XY, Zeng YM Tags: Chin Med J (Engl) Source Type: research

Role of the Ca2+-Calcineurin-Nuclear Factor of Activated T cell Pathway in Mitofusin-2-Mediated Immune Function of Jurkat Cells.
CONCLUSIONS: Our findings suggest that MFN2 may regulate T cell immune functions primarily through the Ca2+-calcineurin-NFAT pathway. MFN2 may represent a potential therapeutic target for T cell immune dysfunction-related diseases. PMID: 29363649 [PubMed - in process]
Source: Chinese Medical Journal - January 26, 2018 Category: General Medicine Authors: Xu XP, Yao YM, Zhao GJ, Wu ZS, Li JC, Jiang YL, Lu ZQ, Hong GL Tags: Chin Med J (Engl) Source Type: research

Cigarette smoke enhances human rhinovirus-induced CXCL8 production via HuR-mediated mRNA stabilization in human airway epithelial cells
Background: Human rhinovirus (HRV) triggers exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Cigarette smoking is the leading risk factor for the development of COPD and 25% of asthmatics smoke. Smoking asthmatics have worse symptoms and more frequent hospitalizations compared to non-smoking asthmatics. The degree of neutrophil recruitment to the airways correlates with disease severity in COPD and during viral exacerbations of asthma. We have previously shown that HRV and cigarette smoke, in the form of cigarette smoke extract (CSE), each induce expression of the neutrophil chemoattractant and act...
Source: BioMed Central - August 30, 2013 Category: Journals (General) Authors: Magdalena H HudyDavid Proud Source Type: research