Cigarette smoke enhances human rhinovirus-induced CXCL8 production via HuR-mediated mRNA stabilization in human airway epithelial cells

Conclusions: Induction of CXCL8 by the combination of HRV and CSE is regulated by mRNA stabilization involving HuR. Thus, targeting the HuR pathway may be an effective method of dampening CXCL8 production during HRV-induced exacerbations of lower airway disease, particularly in COPD patients and asthmatic patients who smoke.

http://respiratory-research.com/content/14/1/88

Source: BioMed Central - August 30, 2013 Category: Journals (General) Authors: Magdalena H HudyDavid Proud Source Type: research