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Evaluation of an Integrin αvβ3 Radiotracer, 18FF-FPP-RGD2, for Monitoring Pharmacological Effects of Integrin αv siRNA in the NASH Liver
ConclusionThis study suggests that [18F]F-FPP-RGD2 PET imaging is a promising radiotracer for monitoring hepatic integrin αv protein levels and hepatic function in NASH pathology.
Source: Nuclear Medicine and Molecular Imaging - March 7, 2023 Category: Nuclear Medicine Source Type: research

The preclinical characterization of 18FhGTS13 for imaging of xC- transporter activity
Conclusion: [18F]hGTS13 is a novel radiotracer for measuring xC- transporter activity. It showed high and specific uptake in cell assays with A549 and H460 cells. [18F]hGTS13 showed significantly lower uptake in activated T cells compared to [18F]FSPG. PET/CT imaging of [18F]hGTS13 in H460 tumor bearing rats revealed significantly higher tumor uptake than [18F]FSPG.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Beinat, C., Gowrishanker, G., Shen, B., Alam, I., Robinson, E., Ilovich, O., Koglin, N., Schmitt-Willich, H., Berndt, M., Mueller, A., Zerna, M., Srinivasan, A., Gambhir, S. Tags: Preclinical Probes for Oncology III Source Type: research

Effect of IDH3{alpha} on glucose uptake in lung adenocarcinoma
Conclusion: High expression of IDH3α in lung adenocarcinoma patients showed higher glucose uptake than low expression ones. IDH3α affect glucose uptake of lung cancer through AKT-GLUT1 pathway, the down-regulation of IDH3α can reduce the generation of lactic acid in tumor cells.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Du, B., Li, X., Li, Y. Tags: Basic Science Posters (Oncology) Source Type: research

Role of Adenine Nucleotide Translocase2 on the 18F-FDG uptake and differentiation in cancer
Conclusion: ANT2 expression correlated with FDG uptake in the various cancer cell lines. Higher level of ANT2 expression was observed in dedifferentiated cancer, and this indicates that ANT2 can be used as a marker of malignancy in various cancer. Research Support:
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Lee, C.-H., Youn, H., Kim, M. J., Chai, Y. J., Cho, S. W., Kang, K. W., Chung, J.-K. Tags: Radiochemistry: Imaging of Cancer Source Type: research

The role of monocarboxylate transpoter 1 to uptake acetate in low glycolytic hepatocellular carcinoma cell line HepG2 cells
Conclusions Our data demonstrate that acetate was supported to HCC cells through MCT1 specifically in the low glycolytic cancer cells, and high MCT1 expression is related with low glycolytic phenotype cancer that would be the therapeutic target or diagnosis probe for low glycolytic cancers.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Jeon, J., Lee, M., kim, j., Yun, M. Tags: MTA I: Basic Science Posters Source Type: research