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Promotion of human mesenchymal stem cell osteogenesis by PI3-kinase/Akt signaling, and the influence of caveolin-1/cholesterol homeostasis
Conclusions: PI3K/Akt signaling is a key pathway required for human MSC osteogenesis, and it is likely that localization of active Akt in non-caveolar and caveolar membrane rafts positively and negatively contributes to osteogenesis, respectively.
Source: Stem Cell Research and Therapy - December 1, 2015 Category: Stem Cells Authors: Natasha BakerJihee SohnRocky Tuan Source Type: research

Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF‐1R Onto the Primary Cilium Associated with Cilia Elongation
This study tested the hypothesis that changes in primary cilia structure are required for stem cell differentiation. hMSCs expressed primary cilia which were labelled with acetylated alpha tubulin and visualized by confocal microscopy. Chemically induced differentiation resulted in lineage specific changes in cilia length and prevalence independent of cell cycle. In particular adipogenic differentiation resulted in cilia elongation associated with the presence of dexamethasone, whilst insulin had an inhibitory effect on cilia length. Over a seven day time course adipogenic differentiation media resulted in cilia elongation...
Source: Stem Cells - February 18, 2015 Category: Stem Cells Authors: Melis T. Dalbay, Stephen D. Thorpe, John T. Connelly, J. Paul Chapple, Martin M. Knight Tags: Tissue‐specific stem cells Source Type: research