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Canagliflozin Inhibits Glioblastoma Growth and Proliferation by Activating AMPK
Cell Mol Neurobiol. 2022 Apr 18. doi: 10.1007/s10571-022-01221-8. Online ahead of print.ABSTRACTSodium-glucose transporter 2 (SGLT2) inhibitors are antidiabetic drugs affecting SGLT2. Recent studies have shown various cancers expressing SGLT2, and SGLT2 inhibitors attenuating tumor proliferation. We evaluated the antitumor activities of canagliflozin, a SGLT2 inhibitor, on glioblastoma (GBM). Three GBM cell lines, U251MG (human), U87MG (human), and GL261 (murine), were used. We assessed the expression of SGLT2 of GBM through immunoblotting, specimen-use, cell viability assays, and glucose uptake assay with canagliflozin. T...
Source: Cellular and Molecular Neurobiology - April 18, 2022 Category: Cytology Authors: Kenji Shoda Shohei Tsuji Shinsuke Nakamura Yusuke Egashira Yukiko Enomoto Noriyuki Nakayama Masamitsu Shimazawa Toru Iwama Hideaki Hara Source Type: research

Administration of Interleukin-35-Conditioned Autologous Tolerogenic Dendritic Cells Prolong Allograft Survival After Heart Transplantation
Conclusion: Our data demonstrated that IL-35 induces tolerogenic DCs which are capable of alleviating allograft rejection. Clinical application of IL-35-treated DCs might be a promising approach for eliciting cardiac allograft immune tolerance.Cell Physiol Biochem 2018;49:1221 –1237
Source: Cellular Physiology and Biochemistry - September 7, 2018 Category: Cytology Source Type: research

Concurrent CCR7 Overexpression and RelB Knockdown in Immature Dendritic Cells Induces Immune Tolerance and Improves Skin-Graft Survival in a Murine Model
Conclusion: Transfection with Ad-CCR7 and RelB KD in imDCs may be an effective approach inducing immune tolerance, thus being potentially valuable for inhibiting allograft rejection.Cell Physiol Biochem 2017;42:455 –468
Source: Cellular Physiology and Biochemistry - June 2, 2017 Category: Cytology Source Type: research