Filtered By:
Specialty: Cytology
Nutrition: Zinc
This page shows you your search results in order of date.
Order by Relevance | Date
Total 31 results found since Jan 2013.
ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway
In conclusion, this study uncovers the role of ZNF746 in promoting M2 macrophage polarisation and suggests that ZNF746 may be a promising therapeutic target for limiting BC progression.PMID:37730102 | DOI:10.1016/j.cellsig.2023.110892
Source: Cellular Signalling - September 20, 2023 Category: Cytology Authors: Lu Liu Wen-Yue Zhao Xin-Yu Zheng Source Type: research
SPOP is essential for DNA replication licensing through maintaining translation of CDT1 and CDC6 in HaCaT cells
In this study, we evaluated the cellular functions of wild-type SPOP in non-cancerous human keratinocyte-derived HaCaT cells expressing wild-type SPOP gene. SPOP knockdown using siRNA in HaCaT cells dramatically reduced cell growth and arrested their cell cycles at G1/S phase. The expression of DNA replication licensing factors CDT1 and CDC6 in HaCaT cells drastically decreased on SPOP knockdown as their translation was inhibited. CDT1 and CDC6 downregulation induced p21 expression without p53 activation. Our results suggest that SPOP is essential for DNA replication licensing in non-cancerous keratinocyte HaCaT cells.PMID...
Source: Cell Research - February 15, 2023 Category: Cytology Authors: Sayoko Sanada Masashi Maekawa Sota Tate Hiroki Nakaoka Yasuhiro Fujisawa Koji Sayama Shigeki Higashiyama Source Type: research
Carnosol inhibits KGN cells oxidative stress and apoptosis and attenuates polycystic ovary syndrome phenotypes in mice through Keap1-mediated Nrf2/HO-1 activation
In this study, we established hyperandrogenic PCOS models both in vitro and in vivo. In the human ovarian granulosa cell line, KGN cells, decreased viability and mitochondrial membrane potential, and upregulated reactive oxygen species (ROS) level and apoptosis induced by DHT were partly reversed by carnosol. Western blotting results showed that carnosol treatment inhibited the DHT-activated mitochondrial apoptotic pathway by activating nuclear factor-erythroid 2-related factor (Nrf2)/heme oxygenase 1 (HO-1). Knockdown of Nrf2 by transfecting with siRNA or inhibiting HO-1 by zinc protoporphyrin (ZnPP) blocked the protectiv...
Source: Cell Research - February 14, 2023 Category: Cytology Authors: Rui Ji Fangyuan Jia Xin Chen Yue Gao Jing Yang Source Type: research
Downregulation of Sonic hedgehog signaling induces G2-arrest in genital warts
CONCLUSIONS: The downregulation of the SHh signaling promotes HPV replication and the formation of warts by inducing G2/M arrest in the keratinocytes of CA.PMID:36704875 | DOI:10.1111/srt.13265
Source: Cell Research - January 27, 2023 Category: Cytology Authors: Xiangxi Du Shan Li Kun Yang Yuchun Cao Source Type: research
Zn < sup > 2+ < /sup > protect cardiac H9c2 cells from endoplasmic reticulum stress by preventing mPTP opening through MCU
Cell Signal. 2022 Sep 17:110467. doi: 10.1016/j.cellsig.2022.110467. Online ahead of print.ABSTRACTZn2+ regulates endoplasmic reticulum stress (ERS) and is essential for myocardial protection through gating the mitochondrial permeability transition pore (mPTP). However, the underlining mechanism of the mPTP opening remains uncertain. Cells under sustained ERS induce unfolded protein responses (UPR) and cell apoptosis. Glucose regulatory protein 78 (GRP 78) and glucose regulatory protein 94 (GRP 94) are marker proteins of ERS and regulate the onset of apoptosis through the endoplasmic reticulum signaling pathway. We found t...
Source: Cellular Signalling - September 20, 2022 Category: Cytology Authors: Yang Zhao Pei Wang Tianyu Liu Ying Yang Jiabao Guo Jinkun Xi Yonggui He Source Type: research
ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF- κB Signal Pathways
Biol Trace Elem Res. 2022 Jul 23. doi: 10.1007/s12011-022-03361-w. Online ahead of print.ABSTRACTApoptosis of kidney tubular epithelial cells contributes to diabetic kidney disease (DKD) pathophysiology, but the mechanisms are not fully understood. Zinc transporter protein member 8 (ZnT8, SLC30A8) is a susceptive gene in diabetes. Here, we aim to investigate whether ZnT8 has effects on pathophysiology of DKD. The animal groups include control, ZnT8KO mice, STZ-induced, and ZnT8-KO-STZ. STZ-induced DKD was performed in male C57BL/6 J mice and in ZnT8-KO mice. High glucose (HG)-induced apoptosis in a normal rat kidney tubula...
Source: Cell Research - July 23, 2022 Category: Cytology Authors: Yinmao Chi Xiuli Zhang Dan Liang Yue Wang Xiaoyi Cai Jiqiu Dong Lingzhi Li Zhihong Chi Source Type: research
ULK3-dependent activation of GLI1 promotes DNMT3A expression upon autophagy induction
Autophagy. 2022 Feb 28:1-12. doi: 10.1080/15548627.2022.2039993. Online ahead of print.ABSTRACTMacroautophagy/autophagy is a tightly regulated catabolic process, which contributes at baseline level to cellular homeostasis, and upon its stimulation to the adaptive cellular response to intra- and extracellular stress stimuli. Decrease of autophagy activity is occurring upon aging and thought to contribute to age-related-diseases. Recently, we uncovered, upon autophagy induction, the role of de novo DNMT3A (DNA methyltransferase 3 alpha)-mediated DNA methylation on expression of the MAP1LC3 (microtubule associated protein 1 l...
Source: Autophagy - February 28, 2022 Category: Cytology Authors: Patricia Gonz ález-Rodríguez Mathilde Cheray Lily Keane Pinelopi Engskog-Vlachos Bertrand Joseph Source Type: research
Gene therapy: Comprehensive overview and therapeutic applications
Life Sci. 2022 Feb 3:120375. doi: 10.1016/j.lfs.2022.120375. Online ahead of print.ABSTRACTGene therapy is the product of man's quest to eliminate diseases. Gene therapy has three facets namely, gene silencing using siRNA, shRNA and miRNA, gene replacement where the desired gene in the form of plasmids and viral vectors, are directly administered and finally gene editing based therapy where mutations are modified using specific nucleases such as zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and clustered regulatory interspaced short tandem repeats (CRISPR)/CRISPR-associated protein ...
Source: Cell Research - February 6, 2022 Category: Cytology Authors: Nilofer Sayed Prince Allawadhi Amit Khurana Vishakha Singh Umashanker Navik Sravan Kumar Pasumarthi Isha Khurana Anil Kumar Banothu Ralf Weiskirchen Kala Kumar Bharani Source Type: research
ZNF326 promotes colorectal cancer epithelial-mesenchymal transition
In conclusion, ZNF326 promoted the EMT and invasiveness of colorectal cancer cells. These findings are likely due to LTBP4 and p-Smad2/3 upregulation and, in turn, transforming growth factor beta (TGF-β) signaling activation.PMID:34332402 | DOI:10.1016/j.prp.2021.153554
Source: Cell Research - July 31, 2021 Category: Cytology Authors: Yue Yang Ting Yan Qiang Han Meiyu Zhang Yijun Zhang Yuan Luo Lai Wei Pengcheng Li Enhua Wang Source Type: research
IL-6/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation
Cell Signal. 2021 Jul 9:110082. doi: 10.1016/j.cellsig.2021.110082. Online ahead of print.ABSTRACTGlomerular hypertrophy is a crucial factor of severe podocyte damage and proteinuria. Our previous study showed that high fructose induced podocyte injury. The current study aimed to explore a novel molecular mechanism underlying podocyte hypertrophy induced by high fructose. Here we demonstrated for the first time that high fructose significantly initiated the hypertrophy in rat glomeruli and differentiated human podocytes (HPCs). Consistently, it induced inflammatory response with the down-regulation of anti-inflammatory fac...
Source: Cellular Signalling - July 12, 2021 Category: Cytology Authors: Jie Zhou Jie Yang Yu-Meng Wang Hong Ding Tu-Shuai Li Zhi-Hong Liu Li Chen Rui-Qing Jiao Dong-Mei Zhang Ling-Dong Kong Source Type: research
