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Specialty: Cytology
Condition: Pulmonary Hypertension
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Total 47 results found since Jan 2013.
Contribution of TRPC channels in human and experimental pulmonary arterial hypertension
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00011.2023. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is due to progressive distal pulmonary artery (PA) obstruction leading to right ventricular hypertrophy and failure. Exacerbated store-operated Ca2+ entry (SOCE) contributes to PAH pathogenesis, mediating human PA smooth muscle cells (hPASMCs) abnormalities. The transient receptor potential canonical channels (TRPC family) are Ca2+-permeable channels contributing to SOCE in different cell types, including PASMCs. However, the properties, signaling pathways, and contribution t...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - June 27, 2023 Category: Cytology Authors: Bastien Masson Ana ïs Saint-Martin Willer Mary Dutheil Lucille Penalva H élène Le Ribeuz Kristelle El Jekmek Yann Ruchon Sylvia Cohen-Kaminsky Jessica Sabourin Marc Humbert Olaf Mercier David Montani V éronique Capuano Fabrice Antigny Source Type: research
Inhibition of poly (ADP-ribose) Polymerase-1 (PARP-1) improves endothelial function in pulmonary hypertension
Pulm Pharmacol Ther. 2023 Feb 24:102200. doi: 10.1016/j.pupt.2023.102200. Online ahead of print.ABSTRACTEndothelial dysfunction is critical in the pulmonary vasculature during pulmonary hypertension (PH). Moreover, in PH, increased inflammation and oxidative/nitrosative stress cause DNA damage, activating poly (ADP-ribose) polymerase-1 (PARP-1). Meloche et al. (2014) and our previous research have shown that inhibiting PARP-1 is protective in PH and associated RV hypertrophy. However, the role of PARP-1 in pulmonary arterial endothelial dysfunction has not been explored completely. Therefore, the current study aims to inve...
Source: Cell Research - February 26, 2023 Category: Cytology Authors: Mohammad Shafiq Zahid Rasool Lone Adam Olaitan Abdulkareem Gurpreet Kaur Sai Navya Himalaya Singh Kumaravelu Jagavelu Kashif Hanif Source Type: research
IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis
CONCLUSIONS: IL-11 and IL-11Rα are overexpressed in pulmonary arteries of PH associated to IPF patients, and contributes to pulmonary artery remodeling and PH.PMID:36376885 | DOI:10.1186/s12931-022-02241-0
Source: Cell Research - November 15, 2022 Category: Cytology Authors: Javier Milara In és Roger Paula Montero Enrique Artigues Juan Escriv á Julio Cortijo Source Type: research
DNA-PKcs participated in hypoxic pulmonary hypertension
CONCLUSIONS: Our study indicated the potential mechanism of DNA-PKcs in the development of HPH. It might provide insights into new therapeutic targets for pulmonary vascular remodeling and pulmonary hypertension.PMID:36114572 | DOI:10.1186/s12931-022-02171-x
Source: Cell Research - September 16, 2022 Category: Cytology Authors: Ying-Ying Liu Wei-Yun Zhang Meng-Lan Zhang Yu-Ji Wang Xi-Yan Ma Jung-Hong Jiang Ran Wang Da-Xiong Zeng Source Type: research
Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation
Am J Physiol Lung Cell Mol Physiol. 2022 Mar 23. doi: 10.1152/ajplung.00447.2021. Online ahead of print.ABSTRACTConcentric pulmonary vascular wall thickening due partially to increased PASMC proliferation contributes to elevating PVR in patients with pulmonary hypertension (PH). While pulmonary vasoconstriction may be an early contributor to increasing PVR, the transition of contractile PASMCs to proliferative PASMCs may play an important role in the development and progression of pulmonary vascular remodeling in PH. A rise in cytosolic Ca2+ concentration ([Ca2+]cyt) is a trigger for PASMC contraction and proliferation. He...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 23, 2022 Category: Cytology Authors: Jiyuan Chen Marisela Rodriguez Jinrui Miao Jing Liao Pritesh Prakash Jain Manjia Zhao Tengteng Zhao Aleksandra Babicheva Ziyi Wang Sophia Parmisano Ryan Powers Moreen Matti Cole Paquin Zahra Soroureddin John Y-J Shyy Patricia A Thistlethwaite Ayako Makino Source Type: research
Vascular smooth muscle ROCK1 contributes to hypoxia-induced pulmonary hypertension development in mice
Biochem Biophys Res Commun. 2022 Mar 9;604:137-143. doi: 10.1016/j.bbrc.2022.02.064. Online ahead of print.ABSTRACTRho kinase (ROCK) is implicated in the development of pulmonary arterial hypertension (PAH) in which abnormal pulmonary vascular smooth muscle (VSM) contractility and remodeling lead to right heart failure. Pharmacologic ROCK inhibitors block experimental pulmonary hypertension (PH) development in rodents but can have off-target effects and do not distinguish between the two ROCK forms, ROCK1 and ROCK2, encoded by separate genes. An earlier study using gene knock out (KO) in mice indicated that VSM ROCK2 is re...
Source: Cell Research - March 18, 2022 Category: Cytology Authors: Krishna C Penumatsa Adit A Singhal Rod R Warburton Michael D Bear Chinmayee D Bhedi Sabina Nasirova Jamie L Wilson Guanming Qi Ioana R Preston Nicholas S Hill Barry L Fanburg Young-Bum Kim Deniz Toksoz Source Type: research
