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In Barrett's esophagus patients and Barrett's cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids
Hydrophobic bile acids like deoxycholic acid (DCA), which cause oxidative DNA damage and activate NF-B in Barrett's metaplasia, might contribute to carcinogenesis in Barrett's esophagus. We have explored mechanisms whereby ursodeoxycholic acid (UDCA, a hydrophilic bile acid) protects against DCA-induced injury in vivo in patients and in vitro using nonneoplastic, telomerase-immortalized Barrett's cell lines. We took biopsies of Barrett's esophagus from 21 patients before and after esophageal perfusion with DCA (250 μM) at baseline and after 8 wk of oral UDCA treatment. DNA damage was assessed by phospho-H2AX expression,...
Source: AJP: Gastrointestinal and Liver Physiology - July 15, 2014 Category: Gastroenterology Authors: Peng, S., Huo, X., Rezaei, D., Zhang, Q., Zhang, X., Yu, C., Asanuma, K., Cheng, E., Pham, T. H., Wang, D. H., Chen, M., Souza, R. F., Spechler, S. J. Tags: CALL FOR PAPERS Source Type: research

In Barrett's Esophagus Patients and Barrett's Cell Lines, Ursodeoxycholic Acid Increases Antioxidant Expression and Prevents DNA Damage by Bile Acids.
Abstract Hydrophobic bile acids like deoxycholic acid (DCA), which cause oxidative DNA damage and activate NF-κB in Barrett's metaplasia, might contribute to carcinogenesis in Barrett's esophagus. We have explored mechanisms whereby ursodeoxycholic acid (UDCA, a hydrophilic bile acid) protects against DCA-induced injury in vivo in patients and in vitro using non-neoplastic, telomerase-immortalized Barrett's cell lines. We took biopsies of Barrett's esophagus from 21 patients before and after esophageal perfusion with DCA (250 µM) at baseline, and after 8 weeks of oral UDCA treatment. DNA damage was assessed by p...
Source: Am J Physiol Gastroi... - May 22, 2014 Category: Gastroenterology Authors: Peng S, Huo X, Rezaei D, Zhang Q, Zhang X, Yu C, Asanuma K, Cheng E, Pham TH, Wang DH, Chen M, Souza RF, Spechler SJ Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research