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Corticosteroid Regulates Epithelial Occludin Expression in Nasal Polyps through a MKP-1-Dependent Pathway
Objective: To evaluate the regulatory effect of corticosteroid on occludin expression in polyp tissues of chronic rhinosinusitis with nasal polyps (CRSwNP) patients and in vitro. Methods: Twenty CRSwNP patients were enrolled and subjected to prednisone (30 mg/day for 14 days). The expression of occludin in polyp tissues was examined before and after treatment using immunohistochemical staining and quantitative reverse transcription polymerase chain reaction. Moreover, the expression of occludin in polyp-derived epithelial cells (PECs) and human bronchial epithelial cells (BECs) was examined using Western blot analysis in t...
Source: ORL - November 19, 2014 Category: ENT & OMF Source Type: research

Enhanced expression of SAM‐pointed domain–containing Ets‐like factor in Chronic rhinosinusitis with nasal polyps
ConclusionsOur findings suggested that SPDEF may be regarded as a promising therapeutic target for modulating mucus hypersecretion in CRSwNP. Level of EvidenceN/A. Laryngoscope, 2014
Source: The Laryngoscope - November 6, 2014 Category: ENT & OMF Authors: Jing Bai, Beiping Miao, Xingmei Wu, Xi Luo, Renqiang Ma, Jia Zhang, Lei Li, Jianbo Shi, Huabin Li Tags: Allergy/Rhinology Source Type: research