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Gut Bacterial Metabolite Urolithin A Decreases Actin Polymerization and Migration in Cancer Cells
ConclusionUA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary UA in cancer prevention or as adjuvant therapy is promising.
Source: Molecular Nutrition and Food Research - February 17, 2020 Category: Food Science Authors: Md Alauddin, Toshiyuki Okumura, Janet Rajaxavier, Shayan Khozooei, Simone P öschel, Satoru Takeda, Yogesh Singh, Sara Y Brucker, Diethelm Wallwiener, André Koch, Madhuri S Salker Tags: Research Article Source Type: research

Luteolin Ameliorates Testis Injury and Blood –Testis Barrier Disruption through the Nrf2 Signaling Pathway and by Upregulating Cx43
ConclusionLuteolin is identified as a novel active ingredient that contributes to the protective activity in testicular damage through activating the Nrf2 signaling pathway and by upregulating Cx43.
Source: Molecular Nutrition and Food Research - April 15, 2019 Category: Food Science Authors: Bo Ma, Jie Zhang, Zhiming Zhu, Ang Zhao, Yanfen Zhou, Hanjie Ying, Qi Zhang Tags: Research Article Source Type: research

Potential role of nucleoside diphosphate kinase in myricetin-induced selective apoptosis in colon cancer HCT-15  cells.
In this study, we evaluated the anti-cancer effects induced by MYR treatment in colon cancer HCT-15 cells. To detect cell proliferation, we conducted MTT assay and real time-cell electronic sensing (RT-CES). We next performed comet assay and Annexin V and PI staining to detect cellular apoptotic features. After that, we conducted two-dimensional electrophoresis (2-DE) analysis to identify apoptotic proteins. The results of this analysis revealed that eight spots were differentially expressed. Among the spots, we selected nucleoside diphosphate kinase (NDPK) for further investigation, as it has been shown to regulate canc...
Source: Food and Chemical Toxicology - April 23, 2018 Category: Food Science Authors: Lee JH, Choi YJ, Park SH, Nam MJ Tags: Food Chem Toxicol Source Type: research