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Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells
In conclusion, the results demonstrated that the molecular mechanisms of quercetin in regulating apoptosis and autophagy-related pathways and increasing GEM chemosensitivity in pancreatic cancer cells involved inhibition of RAGE expression.Graphical abstractThis diagram illustrated that quercetin treatment effectively attenuated RAGE expression to facilitate autophagy, apoptosis, and GEM chemosensitivity in MIA Paca-2 and MIA Paca-2 GEMR cells.
Source: Journal of Food and Drug Analysis - August 22, 2019 Category: Food Science Source Type: research

Luteolin Ameliorates Testis Injury and Blood –Testis Barrier Disruption through the Nrf2 Signaling Pathway and by Upregulating Cx43
ConclusionLuteolin is identified as a novel active ingredient that contributes to the protective activity in testicular damage through activating the Nrf2 signaling pathway and by upregulating Cx43.
Source: Molecular Nutrition and Food Research - April 15, 2019 Category: Food Science Authors: Bo Ma, Jie Zhang, Zhiming Zhu, Ang Zhao, Yanfen Zhou, Hanjie Ying, Qi Zhang Tags: Research Article Source Type: research

Luteolin Ameliorates Testis Injury and Blood ‐Testis Barrier Disruption through the Nrf2 Signaling Pathway and by Up‐Regulating Cx43
Conclusion: Luteolin was identified as a novel active ingredient that contributed to the protective activity in testicular damage through activating the Nrf2 signaling pathway and by up ‐regulating Cx43.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - March 28, 2019 Category: Food Science Authors: Bo Ma, Jie Zhang, Zhiming Zhu, Ang Zhao, Yanfen Zhou, Hanjie Ying, Qi Zhang Tags: Research Article Source Type: research

Fisetin inhibits cell migration via inducing HO-1 and reducing MMPs expression in breast cancer cell lines.
Abstract Metastasis is commonly seen in advanced stage of cancers, and matrix metalloproteinases (MMPs) are commonly up-regulated and have been identified as critical regulators. In this present study, a flavonoid, fisetin, which can be found in diverse foods, is investigated for its ability to inhibit cell motility, and the underlying mechanism is also studied in breast cancer cells (4T1 and JC cells). We have revealed that fisetin increased HO-1 mRNA and protein expressions. Besides, fisetin also elevated Nrf2 expression in nuclear fraction. By silencing Nrf2, fisetin-induced HO-1 expression was abrogated, sugge...
Source: Food and Chemical Toxicology - August 1, 2018 Category: Food Science Authors: Tsai CF, Chen JH, Chang CN, Lu DY, Chang PC, Wang SL, Yeh WL Tags: Food Chem Toxicol Source Type: research

Potential role of nucleoside diphosphate kinase in myricetin-induced selective apoptosis in colon cancer HCT-15  cells.
In this study, we evaluated the anti-cancer effects induced by MYR treatment in colon cancer HCT-15 cells. To detect cell proliferation, we conducted MTT assay and real time-cell electronic sensing (RT-CES). We next performed comet assay and Annexin V and PI staining to detect cellular apoptotic features. After that, we conducted two-dimensional electrophoresis (2-DE) analysis to identify apoptotic proteins. The results of this analysis revealed that eight spots were differentially expressed. Among the spots, we selected nucleoside diphosphate kinase (NDPK) for further investigation, as it has been shown to regulate canc...
Source: Food and Chemical Toxicology - April 23, 2018 Category: Food Science Authors: Lee JH, Choi YJ, Park SH, Nam MJ Tags: Food Chem Toxicol Source Type: research