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Punicalagin, a Pomegranate ‐Derived Ellagitannin, Suppresses Obesity and Obesity‐Induced Inflammatory Responses Via the Nrf2/Keap1 Signaling Pathway
ConclusionsPCG ameliorated obesity and obesity ‐induced inflammatory responses via activation of Nrf2/Keap1 signaling, suggesting that PCG has potential as an oral agent to control obesity‐mediated diseases.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - August 23, 2019 Category: Food Science Authors: Bobin Kang, Chae Young Kim, Jisu Hwang, Kyungae Jo, Singeun Kim, Hyung Joo Suh, Hyeon ‐Son Choi Tags: Research Article Source Type: research

Attenuation of Palmitic Acid –Induced Lipotoxicity by Chlorogenic Acid through Activation of SIRT1 in Hepatocytes
ConclusionCollectively, these findings show that supplementation with CGA protects hepatocytes from FFA ‐induced lipotoxicity through activation of SIRT1, which reverses the oxidative stress and dysfunction of mitochondrial biogenesis directly.
Source: Molecular Nutrition and Food Research - June 12, 2019 Category: Food Science Authors: Lele Yang, Jinchao Wei, Feiya Sheng, Peng Li Tags: Research Article Source Type: research

Attenuation of Palmitic Acid ‐Induced Lipotoxicity by Chlorogenic Acid Through Activation of SIRT1 in Hepatocytes
ConclusionCollectively, these findings show that supplementation with CGA protected hepatocytes from FFAs ‐induced lipotoxicity through activation of SIRT1, which reversed the oxidative stress and dysfunction of mitochondrial biogenesis directly.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - June 4, 2019 Category: Food Science Authors: Lele Yang, Jinchao Wei, Feiya Sheng, Peng Li Tags: Research Article Source Type: research

Luteolin Ameliorates Testis Injury and Blood –Testis Barrier Disruption through the Nrf2 Signaling Pathway and by Upregulating Cx43
ConclusionLuteolin is identified as a novel active ingredient that contributes to the protective activity in testicular damage through activating the Nrf2 signaling pathway and by upregulating Cx43.
Source: Molecular Nutrition and Food Research - April 15, 2019 Category: Food Science Authors: Bo Ma, Jie Zhang, Zhiming Zhu, Ang Zhao, Yanfen Zhou, Hanjie Ying, Qi Zhang Tags: Research Article Source Type: research

Luteolin Ameliorates Testis Injury and Blood ‐Testis Barrier Disruption through the Nrf2 Signaling Pathway and by Up‐Regulating Cx43
Conclusion: Luteolin was identified as a novel active ingredient that contributed to the protective activity in testicular damage through activating the Nrf2 signaling pathway and by up ‐regulating Cx43.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - March 28, 2019 Category: Food Science Authors: Bo Ma, Jie Zhang, Zhiming Zhu, Ang Zhao, Yanfen Zhou, Hanjie Ying, Qi Zhang Tags: Research Article Source Type: research

Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2.
Abstract Z-Ligustilide is the most potent bioactive component of Angelica sinensis, which is widely used in Chinese traditional medicine. Z-Ligustilide selectively affected ovarian cancer cell survival in a dose dependent manner. Z-Ligustilide induced apoptotic cell death was determined by flow cytometry. We also demonstrated that apoptotic cell death was triggered by Z-Ligustilideinduced oxidative stress and mitochondria played an active role. Mitochondrial polarization was reduced by Z-Ligustilidewhereas mitochondrial superoxide formation was increased. NRF2 was induced by Z-Ligustilide in OVCAR-3 cells at epi...
Source: Food and Chemical Toxicology - September 20, 2018 Category: Food Science Authors: Lang F, Qu J, Yin H, Li L, Zhi Y, Liu Y, Fang Z, Hao E Tags: Food Chem Toxicol Source Type: research

Oxyresveratrol stimulates mucin production in an NAD+-dependent manner in human intestinal goblet cells.
In conclusion, OXY increases NAD+ levels, resulting in the stimulation of MUC2 expression in LS 174T cells. These findings present a novel role for NAD+ in stimulation of MUC2 expression. PMID: 29935245 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - June 20, 2018 Category: Food Science Authors: Hwang D, Jo H, Ma SH, Lim YH Tags: Food Chem Toxicol Source Type: research