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Withanolide modulates the potential crosstalk between apoptosis and autophagy in different colorectal cancer cell lines
Eur J Pharmacol. 2022 Jun 21:175113. doi: 10.1016/j.ejphar.2022.175113. Online ahead of print.ABSTRACTWithaferin A (WFA), a withanolide, is isolated from plants of Withania somnifera (L.) Dual (Solanaceae), known as Indian ginseng, Indian winter cherry or Ashwagandha. It has been reported to exert multifaceted anti-neoplastic effects. Here, we analyzed the impact of WFA on apoptosis and autophagy activation in different human colorectal cancer cell lines. We observed that WFA exposure caused an increased aggregation of cells in the subG1 arrest in cell cycle, and increased the number of late apoptotic cells. WFA also induc...
Source: European Journal of Pharmacology - June 24, 2022 Category: Drugs & Pharmacology Authors: Young Yun Jung Jae-Young Um Arunachalam Chinnathambi Chandramohan Govindasamy Acharan S Narula Ojas A Namjoshi Bruce E Blough Gautam Sethi Kwang Seok Ahn Source Type: research

Blockade of TRPM7 Alleviates Chondrocyte Apoptosis and Articular Cartilage Damage in the Adjuvant Arthritis Rat Model Through Regulation of the Indian Hedgehog Signaling Pathway
This study focused on the effects of TRPM7 on arthritic chondrocyte injury and its underlying mechanisms of action. Sodium nitroprusside (SNP)-induced rat primary chondrocyte apoptosis and rat adjuvant arthritis (AA) were used as in vitro and in vivo models, respectively. Blockage of TRPM7 with 2-APB or specific siRNA resulted in increased chondrocyte viability and reduced toxicity of SNP. Moreover, treatment with 2-APB enhanced the Bcl-2/Bax ratio and reduced cleaved PARP and IL-6, MMP-13 and ADAMTS-5 expression in SNP-treated chondrocytes. Activation of Indian Hedgehog with purmorphamine reversed the protective effects o...
Source: Frontiers in Pharmacology - April 13, 2021 Category: Drugs & Pharmacology Source Type: research

Strategic Design of Dicer Substrate siRNA to Mitigate the Resistance Mediated by ABCC1 in Doxorubicinresistant Breast Cancer
A. K. GATTA, R. CHANDRASHEKHAR, N. UDUPA, M. S. REDDY, S. MUTALIK AND V. R. JOSYULA*
Source: Indian Journal of Pharmaceutical Sciences - August 19, 2020 Category: Drugs & Pharmacology Source Type: research

Differential effects of performance-enhancing drugs 'Methamphetamine' and 'hCG' on ex-vivo cultured primary blood mononuclear cells of male athletes.
CONCLUSION: This study demonstrated the differential effects of Meth and hCG on immune cells of athlete's blood. Meth acted as an inflammation and T cell dysfunction inducing agent, while hCG acted as an anti-inflammatory immunosuppressive molecule. PMID: 32124391 [PubMed - as supplied by publisher]
Source: Pharmacological Reports - March 1, 2020 Category: Drugs & Pharmacology Authors: Pramanik A, Das S, Khanna GL Tags: Pharmacol Rep Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Targeted regulation of Rell2 by microRNA-18a is implicated in the anti-metastatic effect of polyphyllin VI in breast cancer cells.
Abstract Polyphyllin VI (PP-VI) is one of the major saponins present in Paris polyphylla Sm., a medicinal plant primarily used for cancer treatment in China and India. However, its anti-metastatic activity remains largely unknown. The current study thus investigated the anti-metastatic activity of PP-VI in mouse mammary carcinoma 4T1 and human breast cancer MDA-MB-231 cells. The anti-metastatic effect of PP-VI was investigated at a sub-cytotoxic dose in migration and invasion assays in vitro. Experimental metastasis mouse model was used to examine the anti-metastatic effect of PP-VI in vivo. Additionally, target p...
Source: European Journal of Pharmacology - February 24, 2019 Category: Drugs & Pharmacology Authors: Wang P, Yang Q, Du X, Chen Y, Zhang T Tags: Eur J Pharmacol Source Type: research