Filtered By:
Specialty: Drugs & Pharmacology
Condition: Hypertension
This page shows you your search results in order of date.
Order by Relevance | Date
Total 50 results found since Jan 2013.
GRK2 expression and catalytic activity are essential for vasoconstrictor / ERK-stimulated arterial smooth muscle proliferation
Biochem Pharmacol. 2023 Sep 8:115795. doi: 10.1016/j.bcp.2023.115795. Online ahead of print.ABSTRACTProlonged vasoconstrictor signalling found in hypertension, increases arterial contraction, and alters vessel architecture by stimulating arterial smooth muscle cell (ASMC) growth, underpinning the development of re-stenosis lesions and vascular remodelling. Vasoconstrictors interact with their cognate G protein coupled receptors activating a variety of signalling pathways to promote smooth muscle proliferation. Here, angiotensin II (AngII) and endothelin 1 (ET1), but not UTP stimulates ASMC proliferation. Moreover, siRNA-me...
Source: Biochemical Pharmacology - September 10, 2023 Category: Drugs & Pharmacology Authors: Asma Alonazi Craig A Nash Chuan-Han Wang Elena Christofidou R A John Challiss Jonathon M Willets Source Type: research
Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and inflammation by regulating CCN1
Biomed Pharmacother. 2023 May 20;164:114920. doi: 10.1016/j.biopha.2023.114920. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is a chronic obstructive disease characterized by vascular remodeling. Studies have confirmed that ginsenoside Rg1 can improve pulmonary hypertension to a certain extent, but the potential mechanism by which it improves hypoxia-induced PAH remains unclear. The aim of this study was to investigate the therapeutic effect of ginsenoside Rg1 on hypoxia-induced PAH. The results showed that hypoxia promoted inflammation, EndMT, and vascular remodeling, which were accompanied by decre...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 22, 2023 Category: Drugs & Pharmacology Authors: Bai-Lin Tang Yu Liu Jing-Liang Zhang Mei-Li Lu Hong-Xin Wang Source Type: research
Melatonin activates the Mst1-Nrf2 signaling to alleviate cardiac hypertrophy in pulmonary arterial hypertension
This study aims to suggest one such possible treatment, through investigating the cardio-protective capabilities of the anti-oxidant, melatonin (Mel), for treating adverse RV remodeling in PAH, along with its underlying mechanisms. Arginine vasopressin induced neonatal rat cardiomyocyte hypertrophy in vitro; in vivo, PAH was induced in rats through intraperitoneal monocrotaline (MCT) injections, and Mel was administered intraperitoneally 24 h prior to MCT. Mel reduced rat cardiomyocyte hypertrophy and mitochondrial oxidative stress in vitro by activating the Mst1-Nrf2 pathway, which were all reversed upon siRNA knockdown o...
Source: European Journal of Pharmacology - September 13, 2022 Category: Drugs & Pharmacology Authors: Shuang Chen Ping Sun You Li Wenqian Shen Chao Wang Peng Zhao Hao Cui Jing-Yi Xue Guo-Qing Du Source Type: research
Upregulated ClC3 channels/transporters elicit swelling-activated Cl < sup > - < /sup > currents and induce excessive cell proliferation in idiopathic pulmonary arterial hypertension
Biol Pharm Bull. 2022 Aug 20. doi: 10.1248/bpb.b22-00513. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is characterized by vascular remodeling of the pulmonary artery, which is mainly attributed to the excessive proliferation of pulmonary arterial smooth muscle cells (PASMCs) comprising the medial layer of pulmonary arteries. The activity of ion channels associated with cytosolic Ca2+ signaling regulates the pathogenesis of PAH. Limited information is currently available on the role of Cl- channels in PASMCs. Therefore, the functional expression of ClC3 channels/transporters was herein investigated i...
Source: Biological and Pharmaceutical Bulletin - August 21, 2022 Category: Drugs & Pharmacology Authors: Taiki Amano Aya Yamamura Moe Fujiwara Seiji Hirai Rubii Kondo Yoshiaki Suzuki Hisao Yamamura Source Type: research
PPAR γ activation inhibits PDGF-induced pulmonary artery smooth muscle cell proliferation and migration by modulating TERT
This study aims to explore whether TERT mediates the proliferation and migration of PASMCs and the underlying molecular mechanism. Primary PASMCs from Sprague-Dawley (SD) rats were used in this experiment. Cell proliferation and migration were evaluated by Cell Counting Kit-8, EdU incorporation assay and transwell assay, respectively. Telomerase activity was assessed with a rat TE ELISA kit. Small interfering RNA (siRNA) transfection was conducted to silence c-MYC expression. The protein levels of p-Akt, c-MYC, PPARγ and TERT were determined through western blotting. Our work demonstrates that PDGF upregulated TERT expres...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 11, 2022 Category: Drugs & Pharmacology Authors: Qianqian Zhang Wei Feng Qingting Wang Jian Wang Limin Chai Yuqian Chen Yan Wang Jin Liu Manxiang Li Xinming Xie Source Type: research
