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Expressions of peroxisome proliferator‐activated receptors (PPARs) are directly influenced by permeability barrier abrogation and inflammatory cytokines and depressed PPARα modulates expressions of chemokines and epidermal differentiation‐related molecules in keratinocytes
In conclusion, depressed PPARα in keratinocytes might be involved in a relationship between permeability barrier abrogation and allergic inflammation and could be a therapeutic target which accounts for both the aspects in AD.
Source: Experimental Dermatology - August 16, 2013 Category: Dermatology Authors: Yasuko Adachi, Yutaka Hatano, Takashi Sakai, Sakuhei Fujiwara Tags: Letter to the Editor Source Type: research

Expressions of PPARs are directly influenced by permeability barrier abrogation and inflammatory cytokines and depressed PPARα modulates expressions of chemokines and epidermal differentiation‐related molecules in keratinocytes
In conclusion, depressed PPARα in keratinocytes might be involved in a relationship between permeability barrier abrogation and allergic inflammation and could be a therapeutic target which accounts for both the aspects in AD. This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - June 29, 2013 Category: Dermatology Authors: Yasuko Adachi, Yutaka Hatano, Takashi Sakai, Sakuhei Fujiwara Tags: Letter to the Editor Source Type: research

Depressed PPARα accelerates a vicious cycle between allergic inflammation and barrier dysfunction
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors and are of three subtypes: PPARα, PPARβ/δ and PPARγ. Activation of PPARs not only has positive effects on permeability barrier homeostasis but also has anti-inflammatory effects. Reduced expression of PPARα in lesional skin in atopic dermatitis (AD) and the preventive and therapeutic effects of a synthetic ligand for PPARα on AD-like dermatitis in a hapten-induced model of AD in mice have been demonstrated. Epidermal levels of expression of PPARα but of neither PPARβ/δ nor PPARγ were reduced in mice with hapten-induced AD. Expressio...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Yasuko Adachi, Yutaka Hatano, Takashi Sakai, Sakuhei Fujiwara Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research