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Pathogenesis of Chronic Allograft Dysfunction Progress to Renal Fibrosis.
Authors: Yang C, Qi R, Yang B Abstract Kidney transplantation is a life-change measurement for the patients of end-stage renal disease (ESRD). However, the renal allograft cannot avoid initial acute kidney injury (AKI) and subsequent chronic allograft dysfunction (CAD), gradually develops fibrosis and eventually loses function. It is imperative to disclose the pathogenesis of AKI and CAD in order to facilitate interventions. We have studied the involvement of immunity, inflammation, and apoptosis in ischemia-reperfusion injury (IRI) and/or immunosuppressant induced AKI models, with associated chronic damage. Our re...
Source: Advances in Experimental Medicine and Biology - August 12, 2019 Category: Research Tags: Adv Exp Med Biol Source Type: research

Fighting against kidney diseases with small interfering RNA: opportunities and challenges
The significant improvements in siRNA therapy have been achieved, which have great potential applications in humans. The kidney is a comparatively easy target organ of siRNA therapy due to its unique structural and functional characteristics. Here, we reviewed recent achievements in siRNA design, delivery and application with focuses on kidney diseases, in particular kidney transplant-related injuries. In addition, the strategy for increasing serum stability and immune tolerance of siRNA was also discussed. At last, the future challenges of siRNA therapy including organ/tissue/cell-specific delivery and time-controlled sil...
Source: Journal of Translational Medicine - February 1, 2015 Category: Research Authors: Cheng YangChao ZhangZitong ZhaoTongyu ZhuBin Yang Source Type: research

Innate immunity activation involved in unprotected porcine auto-transplant kidneys preserved by naked caspase-3 siRNA
Conclusions: The activation of innate immunity with amplified inflammatory responses in the caspase-3 siRNA preserved auto-transplant kidneys are associated with increased TLR3, TLR7 and PKR, which might be due to complementary systemic feedback, although persistent actions initiated by short-acting caspase-3 siRNA cannot be completely ruled out. These results provided valuable evidence to guide future siRNA design and pre-clinic studies.
Source: Journal of Translational Medicine - September 13, 2013 Category: Research Authors: Cheng YangLong LiYinjia XueZitong ZhaoTian ZhaoYichen JiaRuiming RongMing XuMichael NicholsonTongyu ZhuBin Yang Source Type: research