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Altered tooth morphogenesis after silencing the planar cell polarity core component, Vangl2
In this study, we show that Vangl2 is expressed in the inner dental epithelium (IDE) and in the secondary enamel knots (SEKs) of bell stage tooth germs. Inhibition of Vangl2 expression by siRNA treatment in in vitro-cultured tooth germs resulted in retarded tooth germ growth with deregulated cell proliferation and apoptosis. After kidney transplantation of Vangl2 siRNA-treated tooth germs, teeth were observed to be small and malformed. We also show that Vangl2 is required to maintain the proper pattern of cell alignment in SEKs, which maybe important for the function of SEKs as signaling centers. These results suggest that...
Source: Cell and Tissue Research - September 2, 2016 Category: Cytology Source Type: research

Involvement of Caveolin-1 in CD83 internalization in Mouse Dendritic cells.
In conclusion, our data indicated that a Caveolin-dependent endocytic pathway is involved in CD83 internalization in DCs and that Caveolin-1 is involved in the activity of DCs. PMID: 24898475 [PubMed - as supplied by publisher]
Source: Cell Transplantation - June 3, 2014 Category: Cytology Authors: Yang Y, Xin Z, Chu J, Li N, Sun T Tags: Cell Transplant Source Type: research