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Inhibition of adenovirus multiplication by short interfering RNAs directly or indirectly targeting the viral DNA replication machinery
Publication date: June 2012 Source:Antiviral Research, Volume 94, Issue 3 Author(s): Doris Kneidinger , Mirza Ibrišimović , Thomas Lion , Reinhard Klein Human adenoviruses are a common threat to immunocompromised patients, e.g., HIV-positive individuals or solid-organ and, in particular, allogeneic stem cell transplant recipients. Antiviral drugs have a limited effect on adenoviruses, and existing treatment modalities often fail to prevent fatal outcome. Silencing of viral genes by short interfering RNAs (siRNAs) holds a great promise in the treatment of viral infections. The aim of the present study was to identify ad...
Source: Antiviral Therapy - November 16, 2014 Category: Virology Source Type: research
