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Exogenous H2S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes
This study investigated cardiac function, ultrastructural changes in the ER and mitochondria, apoptotic rate using TUNEL, and the expression of ER stress-associated proteins and mitochondrial apoptotic proteins in cardiac tissues in STZ-induced type I diabetic rats treated with or without NaHS (donor of H2S). Mitochondria of cardiac tissues were isolated, and MPTP opening and cytochrome c (cyt C) and Mfn-2 expression were also detected. Our data showed that hyperglycemia decreased the cardiac function by ultrasound cardiogram, and the administration of exogenous H2S ameliorated these changes. We demonstrated that the expre...
Source: AJP: Endocrinology and Metabolism - March 1, 2017 Category: Endocrinology Authors: Yang, F., Yu, X., Li, T., Wu, J., Zhao, Y., Liu, J., Sun, A., Dong, S., Wu, J., Zhong, X., Xu, C., Lu, F., Zhang, W. Tags: Research Article Source Type: research

Exogenous H2S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes.
CONCLUSION: Hyperglycemia stimulated ER interactions and mitochondrial apoptotic pathways, which were inhibited by exogenous H2S treatment through the regulation of Mfn-2 expression. PMID: 27998959 [PubMed - as supplied by publisher]
Source: Am J Physiol Endocri... - December 19, 2016 Category: Endocrinology Authors: Yang F, Yu X, Li T, Wu J, Zhao Y, Sun A, Dong S, Wu J, Zhong X, Xu C, Lu F, Zhang W Tags: Am J Physiol Endocrinol Metab Source Type: research

Gene interference strategies as a new tool for the treatment of prostate cancer
Abstract Prostate cancer (PCa) is one of the most common cancer in men. It affects older men and the incidence increases with age; the median age at diagnosis is 67 years. The diagnosis of PCa is essentially based on three tools: digital rectal exam, serum concentration of prostate specific antigen, and transrectal ultrasound-guided biopsy. Currently, the therapeutic treatments of this cancer are different and range from the prostatectomy to hormonal therapy, to radiation therapy, to immunotherapy, and to chemotherapy. However, additional efforts are required in order to find new weapons for the treatment of meta...
Source: Endocrine - June 7, 2015 Category: Endocrinology Source Type: research

Rap1 ameliorates renal tubular injury in diabetic nephropathy.
Abstract Rap1b ameliorates high glucose (HG)-induced mitochondrial dysfunction in tubular cells. However, its role and precise mechanism in diabetic nephropathy (DN) in vivo remains unclear. We hypothesize that Rap1 plays a protective role in tubular damage of DN by modulating primarily the mitochondria-derived oxidative stress.The role and precise mechanisms of Rap1b on mitochondrial dysfunction and of tubular cells in DN was examined in rats with Streptozotocin (STZ)-induced diabetes that have Rap1b gene transfer using an ultrasound microbubble-mediated technique as well as in renal proximal epithelial tubular c...
Source: Diabetes - December 18, 2013 Category: Endocrinology Authors: Xiao L, Zhu X, Yang S, Liu F, Zhou Z, Zhan M, Xie P, Zhang D, Li J, Song P, Kanwar YS, Sun L Tags: Diabetes Source Type: research