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STRESS granule-associated RNA-binding protein CAPRIN1 drives cancer progression and regulates treatment response in nasopharyngeal carcinoma
In conclusion, CA PRIN1 might drive NPC proliferation, regulate cell cycle and apoptosis, and affect tumor cell response to anti-cancer agents and X-ray irradiation. CAPRIN1 might serve as a potential target for NPC.
Source: Medical Oncology - December 14, 2022 Category: Cancer & Oncology Source Type: research

USP9X Is Required to Maintain Cell Survival in Response to High-LET Radiation
Ionizing radiation (IR) principally acts through induction of DNA damage that promotes cell death, although the biological effects of IR are more broad ranging. In fact, the impact of IR of higher-linear energy transfer (LET) on cell biology is generally not well understood. Critically, therefore, the cellular enzymes and mechanisms responsible for enhancing cell survival following high-LET IR are unclear. To this effect, we have recently performed siRNA screening to identify deubiquitylating enzymes that control cell survival specifically in response to high-LET α-particles and protons, in comparison to low-LET X-rays an...
Source: Frontiers in Oncology - July 1, 2021 Category: Cancer & Oncology Source Type: research

Down-regulation of BTG1 by miR-454-3p enhances cellular radiosensitivity in renal carcinoma cells
Conclusions: Our results indicate that BTG1 is a direct target of miR-454-3p. Down-regulation of BTG1 by miR-454-3p renders tumor cells sensitive to radiation. These results may shed light on the potential application in tumor radiotherapy.
Source: Radiation Oncology - August 12, 2014 Category: Cancer & Oncology Authors: Xin WuNan DingWentao HuJinpeng HeShuai XuHailong PeiJunrui HuaGuangming ZhouJufang Wang Source Type: research