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Preliminary evaluation of a small interfering RNA molecular probe targeting murine double minute 2 in breast cancer
Conclusion The [99mTc]HYNIC-siRNA 1489 was taken up by the tumor, which had a high level of MDM2. The probe exhibited a sufficient retention time in the tumor. This probe may be an effective strategy for evaluating MDM2 expression and achieving early diagnosis in breast cancer.
Source: Nuclear Medicine Communications - July 21, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Non-invasive evaluation of HABP1 expression with < sup > 99m < /sup > Tc-labeled small-interference RNA in ovarian cancer
CONCLUSIONS: We showed that 99mTc-HYNIC-siHABP1 is a feasible probe for the noninvasive visualization of HABP1 expression in ovarian cancer.PMID:34402389 | DOI:10.1080/09553002.2021.1969052
Source: International Journal of Radiation Biology - August 17, 2021 Category: Radiology Authors: Chunyu Duan Yue Gao Sha Luan Shibo Guo Xueliang Cao Peng Xu Peng Fu Changjiu Zhao Source Type: research

Noninvasive evaluation of HABP1 expression with < sup > 99m < /sup > Tc-labeled small-interference RNA in ovarian cancer
CONCLUSIONS: We showed that 99mTc-HYNIC-siHABP1 is a feasible probe for the noninvasive visualization of HABP1 expression in ovarian cancer.PMID:34402389 | DOI:10.1080/09553002.2021.1969052
Source: International Journal of Radiation Biology - August 17, 2021 Category: Radiology Authors: Chunyu Duan Yue Gao Sha Luan Shibo Guo Xueliang Cao Peng Xu Peng Fu Changjiu Zhao Source Type: research

Non-invasive evaluation of HABP1 expression with < sup > 99m < /sup > Tc-labeled small-interference RNA in ovarian cancer
CONCLUSIONS: We showed that 99mTc-HYNIC-siHABP1 is a feasible probe for the noninvasive visualization of HABP1 expression in ovarian cancer.PMID:34402389 | DOI:10.1080/09553002.2021.1969052
Source: International Journal of Radiation Biology - August 17, 2021 Category: Radiology Authors: Chunyu Duan Yue Gao Sha Luan Shibo Guo Xueliang Cao Peng Xu Peng Fu Changjiu Zhao Source Type: research

Superparamagnetic iron oxide nanoparticles mediated 131I-hVEGF siRNA inhibits hepatocellular carcinoma tumor growth in nude mice
Conclusions: EMF-guided 131I-hVEGF siRNA/SilenceMag exhibited an antitumor effect. The synergic therapy of 131I-hVEGF siRNA/SilenceMag might be a promising future treatment option against HCC with the dual functional properties of tumor therapy and imaging.
Source: BMC Cancer - February 21, 2014 Category: Cancer & Oncology Authors: Jing ChenShu ZhuLiangqian TongJiansha LiFei ChenYunfeng HanMing ZhaoWei Xiong Source Type: research