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BMP-9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway.
Abstract The process of vascular calcification shares many similarities with that of physiological skeletal mineralization, and involves the deposition of hydroxyapatite crystals in arteries. However, the cellular mechanisms responsible have yet to be fully explained. Bone morphogenetic protein (BMP-9) has been shown to exert direct effects on both bone development and vascular function. In the present study, we have investigated the role of BMP-9 in vascular smooth muscle cell (VSMC) calcification. Vessel calcification in chronic kidney disease (CKD) begins pre-dialysis, with factors specific to the dialysis mili...
Source: J Cell Mol Med - October 9, 2014 Category: Molecular Biology Authors: Zhu D, Mackenzie NC, Shanahan CM, Shroff RC, Farquharson C, MacRae VE Tags: J Cell Mol Med Source Type: research

BMP‐9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway
Abstract The process of vascular calcification shares many similarities with that of physiological skeletal mineralization, and involves the deposition of hydroxyapatite crystals in arteries. However, the cellular mechanisms responsible have yet to be fully explained. Bone morphogenetic protein (BMP‐9) has been shown to exert direct effects on both bone development and vascular function. In the present study, we have investigated the role of BMP‐9 in vascular smooth muscle cell (VSMC) calcification. Vessel calcification in chronic kidney disease (CKD) begins pre‐dialysis, with factors specific to the dialysis milieu ...
Source: Journal of Cellular and Molecular Medicine - October 9, 2014 Category: Molecular Biology Authors: Dongxing Zhu, Neil Charles Wallace Mackenzie, Catherine M. Shanahan, Rukshana C. Shroff, Colin Farquharson, Vicky Elisabeth MacRae Tags: Original Article Source Type: research