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LIM kinase 1 acts as a profibrotic mediator in permanent atrial fibrillation patients with valvular heart disease.
Abstract Atrial fibrillation (AF) is the most frequently diagnosed cardiac arrhythmia worldwide. Patients with permanent atrial fibrillation are at an increased risk of developing valvular heart disease. Atrial fibrosis occurs in this pathophysiological setting. LIM kinase 1 (LIMK1) is a serine/threonine kinase that regulates microtubule stability and actin polymerization in fibroblasts. LIMK1 has been implicated in the pathogenesis of atrial fibrillation. Clinical data and biopsies of the right atrial appendage were collected from 50 patients with valvular heart disease who underwent heart valve replacement surge...
Source: Journal of Biosciences - February 28, 2019 Category: Biomedical Science Authors: Chen Q, Gimple RC, Li G, Chen J, Wu H, Li R, Xie J, Xu B Tags: J Biosci Source Type: research