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Crosstalk between the activated Slit2 –Robo1 pathway and TGF‐β1 signalling promotes cardiac fibrosis
ConclusionsThe Slit2 –Robo1 signalling pathway interfered with the TGF‐β1/Smad pathway and promoted cardiac fibrosis. Blockade of Slit2–Robo1 might be a new treatment for cardiac fibrosis.
Source: ESC Heart Failure - January 25, 2021 Category: Cardiology Authors: Yunqi Liu, Ziwei Yin, Xueqin Xu, Chen Liu, Xiaoying Duan, Qinlan Song, Ying Tuo, Cuiping Wang, Jing Yang, Shengli Yin Tags: Original Research Article Source Type: research

Human Aortic Valve Interstitial Cells Display Proangiogenic Properties During Calcific Aortic Valve Disease.
CONCLUSIONS: We provide here the first proof of an angiogenic potential of human VICs isolated from patients with calcific aortic valve disease. These results point to a novel function of VICp in valve vascularization during calcific aortic valve disease, with a perivascular differentiation ability and a VEGF-A paracrine effect. Targeting perivascular differentiation and VEGF-A to slow calcific aortic valve disease progression warrants further investigation. PMID: 33147990 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 5, 2020 Category: Cardiology Authors: Gendron N, Rosa M, Blandinieres A, Sottejeau Y, Rossi E, Van Belle E, Idelcadi S, Lecourt S, Vincentelli A, Cras A, Jashari R, Chocron R, Baudouin Y, Pamart T, Bièche I, Nevo N, Cholley B, Rancic J, Staels B, Gaussem P, Dupont A, Carpentier A, Susen S, S Tags: Arterioscler Thromb Vasc Biol Source Type: research

LIM kinase 1 acts as a profibrotic mediator in permanent atrial fibrillation patients with valvular heart disease.
Abstract Atrial fibrillation (AF) is the most frequently diagnosed cardiac arrhythmia worldwide. Patients with permanent atrial fibrillation are at an increased risk of developing valvular heart disease. Atrial fibrosis occurs in this pathophysiological setting. LIM kinase 1 (LIMK1) is a serine/threonine kinase that regulates microtubule stability and actin polymerization in fibroblasts. LIMK1 has been implicated in the pathogenesis of atrial fibrillation. Clinical data and biopsies of the right atrial appendage were collected from 50 patients with valvular heart disease who underwent heart valve replacement surge...
Source: Journal of Biosciences - February 28, 2019 Category: Biomedical Science Authors: Chen Q, Gimple RC, Li G, Chen J, Wu H, Li R, Xie J, Xu B Tags: J Biosci Source Type: research

Wnt3a/β-catenin increases proliferation in heart valve interstitial cells
Conclusion: Wnt3a/β-catenin signaling pathway is an important regulator of proliferation in adult VICs.
Source: Cardiovascular Pathology - August 13, 2012 Category: Cardiology Authors: Songyi Xu, Avrum I. Gotlieb Tags: Original Articles Source Type: research