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DAB2IP-knocking down resulted in radio-resistance of breast cancer cells is associated with increased hypoxia and vasculogenic mimicry formation
Conclusions: Our data support that loss of DAB2IP confers radio-resistance of BCa could be due to increased hypoxia, inhibited vascular maturation and promoted VM formation. STAT3 inhibition could be a potential way to overcome such DAB2IP-deficient induced tolerance in BCT.PMID:36947637 | DOI:10.1080/09553002.2023.2194390
Source: International Journal of Radiation Biology - March 22, 2023 Category: Radiology Authors: Xiangyan Zhang Quanxin Wang Ruiqi Zhang Zhaolu Kong Source Type: research

Abstract P2-11-09: A p53-based strategy for protecting normal breast tissue from chemotherapy-induced damage in breast conserving therapy
Conclusions:Together our data show that the MAPK pathway is hyperactivated in TNBC; inhibiting this pathway impairs tumor growth, but enhances GPNMB, which facilitates mammary tumor growth and metastasis in the setting of Mek-i. These data provide rationale for combined targeting of GPNMB and the MAPK pathway in TNBC.Citation Format: Long M, Huang Y, Liu R, Liu R, Su H. A p53-based strategy for protecting normal breast tissue from chemotherapy-induced damage in breast conserving therapy [abstract]. In: Proceedings of the Thirty-Ninth Annual CTRC-AACR San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Phil...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: M Long, Y Huang, R Liu, , H Su Tags: Poster Session Abstracts Source Type: research