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Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of platycodin D against oxidative stress-induced DNA damage and apoptosis in C2C12 myoblasts.
Abstract Myoblast damage by oxidative stress has been proposed as one of the main causes of skeletal muscle loss due to induction of muscle damage. Platycodin D, a triterpenoid saponin found in the root of Platycodon grandiflorum (Jacq.) A. DC., has been known to possess strong antioxidant activity. However, whether platycodin D can defend myoblasts against oxidative injury remains to be elucidated. Therefore, this study was conducted to investigate the potential protective effects of platycodin D against oxidative stress in mouse myoblast C2C12 cells. The results demonstrated that platycodin D inhibited hydrogen ...
Source: General Physiology and Biophysics - November 1, 2020 Category: Physiology Authors: Choi YH Tags: Gen Physiol Biophys Source Type: research

Broad noncoding transcription suggests genome surveillance by RNA polymerase V Plant Biology
Eukaryotic genomes are pervasively transcribed, yet most transcribed sequences lack conservation or known biological functions. In Arabidopsis thaliana, RNA polymerase V (Pol V) produces noncoding transcripts, which base pair with small interfering RNA (siRNA) and allow specific establishment of RNA-directed DNA methylation (RdDM) on transposable elements. Here, we show that...
Source: Proceedings of the National Academy of Sciences - December 1, 2020 Category: Science Authors: Masayuki Tsuzuki, Shriya Sethuraman, Adriana N. Coke, M. Hafiz Rothi, Alan P. Boyle, Andrzej T. Wierzbicki Tags: Biological Sciences Source Type: research

The effect of RNA polymerase V on 24-nt siRNA accumulation depends on DNA methylation contexts and histone modifications in rice Plant Biology
RNA-directed DNA methylation (RdDM) functions in de novo methylation in CG, CHG, and CHH contexts. Here, we performed map-based cloning of OsNRPE1, which encodes the largest subunit of RNA polymerase V (Pol V), a key regulator of gene silencing and reproductive development in rice. We found that rice Pol V...
Source: Proceedings of the National Academy of Sciences - July 21, 2021 Category: Science Authors: Kezhi Zheng, Lili Wang, Longjun Zeng, Dachao Xu, Zhongxin Guo, Xiquan Gao, Dong-Lei Yang Tags: Plant Biology Biological Sciences Source Type: research

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