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Salidroside attenuates myocardial ischemia/reperfusion injury via AMPK-induced suppression of endoplasmic reticulum stress and mitochondrial fission
In this study, we established a myocardial ischemia/reperfusion (I/R) rat model. Rat hearts exposed to Sal with or without compound C were then subjected to I/R. Further, H9c2 cardiomyocytes were subjected to simulated ischemia/reperfusion (SIR) by hypoxia-reoxygenation. The rats and cardiomyocytes were pretreated with Sal, followed by Compound C and AMPK-siRNA to block AMPK activity. We found that Sal significantly ameliorated cardiac function, mitigated infarct size and serum content of lactate dehydrogenase and creatine kinase, improved mitochondrial function, and reduced mitochondrial fission and apoptosis. Furthermore...
Source: Toxicology and Applied Pharmacology - June 6, 2022 Category: Toxicology Authors: Xin Tian Ye Huang Xiaofeng Zhang Rong Fang Yi Feng Wanfang Zhang Ling Li Tian Li Source Type: research

Molecules, Vol. 21, Pages 1033: Salidroside Suppresses HUVECs Cell Injury Induced by Oxidative Stress through Activating the Nrf2 Signaling Pathway
This study is the first to demonstrate that SAL suppresses HUVECs cell injury induced by oxidative stress through activating the Nrf2 signaling pathway.
Source: Molecules - August 8, 2016 Category: Chemistry Authors: Yao Zhu Ya-Jie Zhang Wei-Wei Liu Ai-Wu Shi Ning Gu Tags: Article Source Type: research