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TRIM13 inhibits cell migration and invasion in clear-cell renal cell carcinoma.
This study explored the clinical significance and biological function of TRIM13 in human RCC. Western blot analyses and Immunohistochemical were performed in RCC tissues. The clinical relevance of TRIM13 in RCC was evaluated by immunohistochemical staining using tissue microarray. The role of TRIM13 in migration was studied in renal cell carcinoma cell lines of 786-O through knocking down TRIM13 with siRNA and over-expression of TRIM13. The regulation of TRIM13 on migration and invasion were determined by wound-healing and transwell assays. Western blot analyses showed that TRIM13 expression was dramatically decreased in R...
Source: Nutrition and Cancer - November 23, 2019 Category: Cancer & Oncology Authors: Li H, Qu L, Zhou R, Wu Y, Zhou S, Zhang Y, Cheng B, Ni J, Huang H, Hou J Tags: Nutr Cancer Source Type: research

Oleic acid promotes cell invasion through an integrin-linked kinase signaling pathway in renal cell carcinoma.
In this study, we further observe the effects of OA on cell invasion of RCC and the potential mechanism by which OA worked was determined. The transwell invasion assay showed OA increased cell invasion of RCC in a dose-dependent manner. Western blotting results indicated ILK, COX-2, and MMP-9 proteins were involved for their high expressions and these effects were reversed when down-regulating the expression of ILK by special siRNA. The MMPs inhibitor GM6001 could weaken the abilities of OA on RCC cells invasion. These results suggested MUFA indeed affected cell invasion of RCC, which was depended by the regulation of ILK ...
Source: Nutrition and Cancer - September 30, 2019 Category: Cancer & Oncology Authors: Liu ZH, Qing CP, Sheng ZZ, Li GZ, Man LB, Xu T Tags: Nutr Cancer Source Type: research