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Naa15 knockdown enhances c2c12 myoblast fusion and induces defects in zebrafish myotome morphogenesis.
Abstract The understanding of muscle tissue formation and regeneration is essential for the development of therapeutic approaches to treat muscle diseases or loss of muscle mass and strength during ageing or cancer. One of the critical steps in muscle formation is the fusion of muscle cells to form or regenerate muscle fibres. To identify new genes controlling myoblast fusion, we performed a siRNA screen in c2c12 myoblasts. The genes identified during this screen were then studied in vivo by knockdown in zebrafish using morpholino. We found that N-alpha-acetyltransferase 15 (Naa15) knockdown enhanced c2c12 myoblas...
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - November 29, 2018 Category: Biochemistry Authors: Monestier O, Landemaine A, Bugeon J, Rescan PY, Gabillard JC Tags: Comp Biochem Physiol B Biochem Mol Biol Source Type: research

LncRNA MALAT1 regulates oxLDL-induced CD36 expression via activating β-catenin.
In conclusion, oxLDL induced MALAT1 transcription and MALAT1 recruits β-catenin to binding sites on the CD36 promoter to induce CD36 expression, which enhances lipid uptake in macrophages. PMID: 29258822 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - December 16, 2017 Category: Biochemistry Authors: Huangfu N, Xu Z, Zheng W, Wang Y, Cheng J, Chen X Tags: Biochem Biophys Res Commun Source Type: research