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Silencing long non-coding RNA MEG3 accelerates tibia fraction healing by regulating the Wnt/ β-catenin signalling pathway.
This study focuses on the effects of epigenetic silencing of long non-coding RNA maternally expressed gene 3 (lncRNA MEG3) on fracture healing by regulating the Wnt/β-catenin signalling pathway. Genes expressed in fracture were screened using bioinformatics and the subcellular location of MEG3 was determined using FISH. Next, we successfully established tibia fracture (TF) models of C57BL/6J and Col2a1-ICAT mice and the effect of silencing lncRNA MEG3 on fracture healing was detected after TF mice were treated with phosphate buffer saline (PBS), MEG3 siRNA and scramble siRNA. X-ray imaging, Safranin-O/fast green and haema...
Source: J Cell Mol Med - April 5, 2019 Category: Molecular Biology Authors: Liu YB, Lin LP, Zou R, Zhao QH, Lin FQ Tags: J Cell Mol Med Source Type: research

MicroRNA-30a ameliorates hepatic fibrosis by inhibiting Beclin1-mediated autophagy.
In conclusion, miR-30a is down-regulated in hepatic fibrosis models and its overexpression prevents liver fibrogenesis by directly suppressing Beclin1-mediated autophagy; therefore, miR-30a may be a new potential therapeutic target for controlling hepatic fibrosis. PMID: 28766848 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - August 1, 2017 Category: Molecular Biology Authors: Chen J, Yu Y, Li S, Liu Y, Zhou S, Cao S, Yin J, Li G Tags: J Cell Mol Med Source Type: research