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Source: J Cell Mol Med
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Total 299 results found since Jan 2013.
Environmental-relevant bisphenol A exposure promotes ovarian cancer stemness by regulating microRNA biogenesis
J Cell Mol Med. 2023 Aug 23. doi: 10.1111/jcmm.17920. Online ahead of print.ABSTRACTBisphenol A (BPA) is a ubiquitous environmental xenobiotic impacting millions of people worldwide. BPA has long been proposed to promote ovarian carcinogenesis, but the detrimental mechanistic target remains unclear. Cancer stem cells (CSCs) are considered as the trigger of tumour initiation and progression. Here, we show for the first time that nanomolar (environmentally relevant) concentration of BPA can markedly increase the formation and expansion of ovarian CSCs concomitant. This effect is observed in both oestrogen receptor (ER)-posit...
Source: J Cell Mol Med - August 23, 2023 Category: Molecular Biology Authors: Sophia S N Lam Zeyu Shi Carman K M Ip Chris K C Wong Alice S T Wong Source Type: research
A pancancer analysis of the oncogenic role of ZNRF2 in human tumours
J Cell Mol Med. 2023 Aug 8. doi: 10.1111/jcmm.17900. Online ahead of print.ABSTRACTFinding effective treatments for cancer requires a thorough understanding of how it develops and progresses. Recent research has revealed the crucial role that Zinc and ring finger 2 (ZNRF2) play in the progression of non-small cell lung cancer (NSCLC) by controlling cell growth and death. However, a comprehensive analysis of ZNRF2's role in cancer as a whole has yet to be conducted. Our study sought to investigate the impact of ZNRF2 on diverse human tumours, as well as the molecular pathways involved, using databases such as TCGA (The Canc...
Source: J Cell Mol Med - August 8, 2023 Category: Molecular Biology Authors: Fujie Shi Yunfei Wu Kai Wang Jiafan Wang Minghui Liu Xinlei Sun Source Type: research
Soluble Sema4D cleaved from osteoclast precursors by TACE suppresses osteoblastogenesis
J Cell Mol Med. 2023 May 11. doi: 10.1111/jcmm.17416. Online ahead of print.ABSTRACTBone remodelling is mediated by orchestrated communication between osteoclasts and osteoblasts which, in part, is regulated by coupling and anti-coupling factors. Amongst formally known anti-coupling factors, Semaphorin 4D (Sema4D), produced by osteoclasts, plays a key role in downmodulating osteoblastogenesis. Sema4D is produced in both membrane-bound and soluble forms; however, the mechanism responsible for producing sSema4D from osteoclasts is unknown. Sema4D, TACE and MT1-MMP are all expressed on the surface of RANKL-primed osteoclast p...
Source: J Cell Mol Med - May 12, 2023 Category: Molecular Biology Authors: Takenobu Ishii Montserrat Ruiz-Torruella Jae Young Kim Hiroyuki Kanzaki Abdullah Albassam Wichaya Wisitrasameewong Satoru Shindo Roodelyne Pierrelus Alireza Heidari Umadevi Kandalam Shin Nakamura Alexandru Movila Dmitriy Minond Toshihisa Kawai Source Type: research
Effect of rapamycin on lysosomal accumulation in a CRISPR/Cas9-based cellular model of VPS13A deficiency
J Cell Mol Med. 2023 May 10. doi: 10.1111/jcmm.17768. Online ahead of print.ABSTRACTVPS13A is a lipid transfer protein localized at different membrane contact sites between organelles, and mutations in the corresponding gene produce a rare neurodegenerative disease called chorea-acanthocytosis (ChAc). Previous studies showed that VPS13A depletion in HeLa cells results in an accumulation of endosomal and lysosomal markers, suggesting a defect in lysosomal degradation capacity leading to partial autophagic dysfunction. Our goal was to determine whether compounds that modulate the endo-lysosomal pathway could be beneficial in...
Source: J Cell Mol Med - May 10, 2023 Category: Molecular Biology Authors: A R Tornero- Écija M A Navas S Mu ñoz-Braceras O Vincent R Escalante Source Type: research
Combined inhibition of XIAP and autophagy induces apoptosis and differentiation in acute myeloid leukaemia
J Cell Mol Med. 2023 May 8. doi: 10.1111/jcmm.17765. Online ahead of print.ABSTRACTPerturbations in autophagy, apoptosis and differentiation have greatly affected the progression and therapy of acute myeloid leukaemia (AML). The role of X-linked inhibitor of apoptosis (XIAP)-related autophagy remains unclear in AML therapeutics. Here, we found that XIAP was highly expressed and associated with poor overall survival in patients with AML. Furthermore, pharmacologic inhibition of XIAP using birinapant or XIAP knockdown via siRNA impaired the proliferation and clonogenic capacity by inducing autophagy and apoptosis in AML cell...
Source: J Cell Mol Med - May 8, 2023 Category: Molecular Biology Authors: Ziyang Huang Jifan Zhou Yinyan Jiang Yixiang Han Xiaofang Wang Fanfan Li Songfu Jiang Kang Yu Shenghui Zhang Source Type: research
Lyn-mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating IRF5 nuclear translocation in spinal dorsal horn
J Cell Mol Med. 2023 May 2. doi: 10.1111/jcmm.17759. Online ahead of print.ABSTRACTThe pro-inflammatory phenotype of microglia usually induces neuroinflammatory reactions in neuropathic pain. Glycometabolism shift to glycolysis can promote the pro-inflammatory phenotype transition of microglia. The omics data analysis suggest a critical role for Lyn dysregulation in neuropathic pain. The present study aimed at exploring the mechanism of Lyn-mediated glycolysis enhancement of microglia in neuropathic pain. Neuropathic pain model was established by chronic constriction injury (CCI), then pain thresholds and Lyn expression we...
Source: J Cell Mol Med - May 3, 2023 Category: Molecular Biology Authors: Erliang Kong Yongchang Li Peng Ma Yixuan Zhang Ruifeng Ding Tong Hua Mei Yang Hongbin Yuan Source Type: research
CX3CL1 induces cell migration and invasion through ICAM-1 expression in oral squamous cell carcinoma cells
J Cell Mol Med. 2023 Apr 21. doi: 10.1111/jcmm.17750. Online ahead of print.ABSTRACTHuman oral squamous cell carcinoma (OSCC) has been associated with a relatively low survival rate over the years and is characterized by a poor prognosis. C-X3-C motif chemokine ligand 1 (CX3CL1) has been involved in advanced migratory cells. Overexpressed CX3CL1 promotes several cellular responses related to cancer metastasis, including cell movement, migration and invasion in tumour cells. However, CX3CL1 controls the migration ability, and its molecular mechanism in OSCC remains unknown. The present study confirmed that CX3CL1 increased ...
Source: J Cell Mol Med - April 21, 2023 Category: Molecular Biology Authors: Chia-Yu Wu Pei-Wen Peng Ting-Yi Renn Chia-Jung Lee Tsung-Ming Chang Augusta I-Chin Wei Ju-Fang Liu Source Type: research
