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Specialty: Endocrinology
Nutrition: Dairy
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Total 4 results found since Jan 2013.
PITX2 regulates steroidogenesis in granulosa cells of dairy goat by the WNT/ β-catenin pathway
Gen Comp Endocrinol. 2022 Mar 14:114027. doi: 10.1016/j.ygcen.2022.114027. Online ahead of print.ABSTRACTPaired-like homeodomain transcription factor 2 (PITX2), a major driver of multiple tissue development, is a transcription factor that regulates gene expression in organisms. However, it is unknown if PITX2 regulates goat granulosa cell (GC) steroidogenesis. Therefore, we investigated the role and mechanism of PITX2 in GC steroidogenesis. In our study, PITX2 significantly facilitated the secretion level of estrogen and progesterone through increasing CYP11A1, CYP19A1, and STAR mRNA and protein expressions in GCs. Further...
Source: General and Comparative Endocrinology - March 18, 2022 Category: Endocrinology Authors: Qiqi Bu Shujuan Liu Zhanhang Wang Jiahao Zou Peijie Wang Heran Cao Dexian Li Binyun Cao Xiaopeng An Yuxuan Song Guang Li Source Type: research
